BACKGROUND It has been demonstrated that brief episodes of sublethal ischemia-reperfusion, so-called ischemic preconditioning, provide powerful tissue protection in different tissues such as heart, brain, skeletal muscle, lung, liver, intestine, kidney, retina, and endothelial cells. Although a recent study has claimed that there are no protective effects of ischemic preconditioning in rat test...

It is estimated that by 2035, more than 130 million adults will suffer from various types of cardiovascular diseases. Therefore, it is very important to know the pathogens of cardiac diseases and investigate new treatments. Also, despite continuous progress in diagnosis, patient education, and risk factor management, myocardial infarction (MI) remains one of the most common causes of morbidity,...

Background—Our laboratory has previously shown that d-opioid receptors are involved in the cardioprotective effect of ischemic preconditioning in the rat heart. However, this class of receptors consists of two subtypes, d1 and d2, and mor k-opioid receptors may also exist in the heart. Therefore, the purpose of the present study was to test the hypothesis that ischemic preconditioning is mediat...

introduction: the purpose of this study was to determine na-ca exchanger 2, 3 (ncx2, 3) protein level changes during 2, 5, 10, 15 days after induction of normobaric hyperoxia (ho) preconditioning. materials and methods: rats were divided in two experimental groups. the first group was exposed to 95% inspired ho for 4 h/day for 6 consecutive days (ho). the second group acted as control, and was ...

introduction: it has been reported that traumas such as transverse abdominal incision before myocardial ischemia result in a significantly decreased infarct size. this phenomenon is named remote preconditioning of trauma. since small skin burn is one of most common traumas, the effect of this injury on ischemia-induced arrhythmias and infarct size was investigated in a rat model of ischemia-rep...

BACKGROUND Low-dose lipopolysaccharide (LPS) preconditioning-induced liver protection has been demonstrated during ischemia-reperfusion injury (IRI) in several organs but has not been sufficiently elucidated underlying causal mechanism. This study investigated the role of low-dose LPS preconditioning on ATF4-CHOP pathway as well as the effects of the pathway on tissue injury and inflammation in...