EVER since the discovery that penicillin was effective against syphilis efforts have been directed to the limitation of the number of injections to be given by the evolution of preparations which are either more slowly absorbed or more slowly excreted. The. slow absorption methods gained the initiative with the introduction in 1945 of penicillin in oil beeswax (Romansky and Rittman) and the suc...

It has been observed that there is a high incidence of treatment failure in cases of ano-rectal gonorrhoea treated by the time-honoured standard methods. At this hospital urethral gonorrhoea has responded well for many years to one injection only of 1-2 m.u. procaine penicillin given intramuscularly; but similar treatment for an ano-rectal infection with gonococci has given very poor results. T...

The safety of long-term prophylactic antiarrhythmic therapy with procaine amide was studied in 78 patients recovering from acute myocardial infarction. Patients were randomly allocated to a control or treatment group and followed monthly for up to 2 years with ambulatory ECG monitoring and measurement of serum drug level, antinuclear antibody (ANA) titer, LE preparation, blood count, BUN, and S...

A non-lethal procedure for identifying pigs apt to develop malignant hyperthermia is described. Susceptible animals were exposed to a variety of anaesthetic and other agents and it was shown that thiopentone sodium and CT 1341 (Glaxo) afforded a measure of protection against the development of the syndrome. Pretreatment with procaine did not prevent the onset of the condition and the administra...

T he occurrence of a reversible lupus-like syndrome in association with procaine amide therapy has been reported a number of times since the initial report by Ladd in 1962.1 Features distinguishing the syndrome from idiopathic systemic lupus erythematosus have been the lack of renal involvement and the disappearance of symptoms and serologic abnormalities upon withdrawal of the drug. Recently w...