To the Editor:—We read with interest the article by Johnson and Swanson on procaine neurotoxicity, and are interested in why they decided to use undiluted 10% procaine instead of 5% procaine prepared with 10% procaine and equal volumes of either 10% glucose or cerebral spinal fluid. When the first report of transient radicular irritation with spinal anesthesia using 5% lidocaine appeared, our d...

To the Editor:—We read with interest the article by Johnson and Swanson on procaine neurotoxicity, and are interested in why they decided to use undiluted 10% procaine instead of 5% procaine prepared with 10% procaine and equal volumes of either 10% glucose or cerebral spinal fluid. When the first report of transient radicular irritation with spinal anesthesia using 5% lidocaine appeared, our d...

A new rapid, specific, and convenient colorimetric method for the determination of procaine hydrochloride in pharmaceutical preparations is described. This method is based on measurement of the intensity of the orange-red color developed when procaine hydrochloride is allowed to react with 1,2-naphthoquinone-4-sulfonic acid sodium salt in aqueous solution. Beer's law is followed over 6.0--20.0 ...

The relationships between the effects of procaine and those of Ca on the spontaneous electrical and mechanical activities of smooth muscle cells of the guinea pig urinary bladder were studied using both microelectrode and sucrose gap methods. Procaine(1, 7, and 15mM) depolarized the membrane and increased spontaneous spike freqency. The maximum rates of rise and fall and the after-hyperpolariza...

INTRODUCTION Periodontitis is a complex pathology characterized by the loss of alveolar bone. The causes and the mechanisms that promote this bone resorption still remain unknown. The knowledge of the critical regulators involved in the alteration of alveolar bone homeostasis is of great importance for developing molecular therapies. Procaine is an anesthetic drug with demethylant properties, m...

OBJECTIVE To determine the durations of the local anesthetic effect and plasma procaine concentrations associated with 5- and 10-mg doses of procaine hydrochloride (with or without 100 microg of epinephrine) administered SC over the lateral palmar digital nerves of horses. ANIMALS 6 healthy adult horses. PROCEDURES The hoof withdrawal reflex latency (HWRL) period was determined by use of a ...

In tests using dogs with ectopic ventricular tachycardia resulting from myocardial infarction, procaine has been found to be without practical value as an ectopic impulse suppressor agent. Procaine amide has proved to be very effective in reducing the ectopic rate of high frequency tachycardias to low levels, thus eliminating danger of death from the tachycardia. Procaine amide usually does not...

Voltage clamp studies with the squid giant axon have shown that changes in the external calcium concentration (Frankenhaeuser and Hodgkin, 1957) shift the sodium and potassium conductance versus membrane potential curves along the potential axis. Taylor (1959) found that procaine acts primarily by reducing the sodium and, to a lesser extent, the potassium conductances. Both procaine and increas...

Neuropathic pain (NPP) is the main culprit among chronic pains affecting the normal life of patients. Procaine is a frequently-used local anesthesia with multiple efficacies in various diseases. However, its role in modulating NPP has not been reported yet. This study aims at uncovering the role of procaine in NPP. Rats were pretreated with procaine by intrathecal injection. Then NPP rat model ...