objective: dendrimers are three-dimensional nanostructures that have numerous applications in medicine, including drug delivery and imaging. although anionic dendrimer polyethylene glycol–citrate has a high potential to increase solubility of water-insoluble drugs and drug delivery, its multi-step synthesis procedure is time consuming. in addition, toxic substances such as dichloromethane are u...

objective(s): we aimed to investigate the influence of transient receptor potential channel 3 (trpc3) on lipopolysaccharide-induced (lps) preterm delivery mice. materials and methods: mice were randomly assigned to the four groups: an unpregnant group, a mid-pregnancy group (e15), a term delivery group, and an lps-induced preterm delivery group (intraperitoneal injection lps at 15 days). uterin...

Nanoemulsion is an alternative and promising approach to overcome insolubility and bioavailability problems of bioactive compounds. In this study, the sonication parameter for preparing nanoemulsions with high α- tocopherol and linolenic acid content were optimized by using response surface methodology and their stability were evaluated during 2 months’ storage. The response surface analysis re...

This study proposes a system dynamics (SD) model to deal with the staged improvement of delivery-orientated production plan. The situations, such as the cycle time affected by total input of human resource, unit transportation cost influenced by amount of delivery quantity, unit penalty (shortage) cost affected by amount of shortages, and the time delay among customer demand, production demand,...

In this paper, we study an integrated production an outbound delivery scheduling problem with a predefined sequence. The manufacturer has to process a set of jobs on a single machine and deliver them in batches to multiple customers. A single vehicle with limited capacity is used for the delivery. Each job has a processing time and a specific customer location. Starting from the manufacturer lo...

In the recent decade, special attention is paid to reverse logistic due to economic benefits of recovery and recycling of used products as well as environmental legislation and social concerns. On the other hand، many researches claim that separately and sequential planning of forward and reverse logistic causes sub-optimality. Effective transport activities are also one of the most important c...

Background: Painless delivery using IV sedation is a method in which the pain and anxiety delivery process will be reduced by IV injection of analgesic and sedative drugs to the mother. In this method the health of neonate is taken into account. Neonate’s health can be measured by Apgar score system. This research was carried out to study Apgar score of the minutes 5 and 10 in neonates born...