Rapid product lifecycles and high development costs pressure manufacturing "rms to cut not only their development times (time-to-market), but also the time to reach full capacity utilization (time-to-volume). The period between completion of development and full capacity utilization is known as production ramp-up. During that time, the new production process is ill understood, which causes low ...

The metabolic consequences of the NADPdependent isocitrate dehydrogenase (IDH) 1 mutation was studied quantitatively in glioblastoma, the most aggressive form of brain tumor. The mutation is found in 70-80% of secondary glioblastoma. Metabolic rewiring of cells due to the mutation causes gliomagenesis by the production of 2-hydroxyglutarate. On the other hand, glioblastoma patients with the IDH...

background: diabetes is one of the most common chronic diseases in which antioxidant capacity changes. omega‑3 fatty acids have extensive biological effects including their advantage on lipoprotein metabolism, platelet function, cytokine production, clotting, fibrinolysis, and inflammatory factors. this study aimed to investigate the effect of omega‑3 fatty acid supplements on antioxidant capac...

N O T E . Charles Gilbert directed the 2002 revision and, along with Kimberly Bayard, William Cleveland, and Dixon Tranum, prepared the revised estimates of industrial production. Norman Morin and John Stevens prepared the revised estimates of capacity and capacity utilization. In late 2002, the Federal Reserve published a revision of its index of industrial production (IP) and the related meas...

This paper considers the comparison of two ðs; SÞ production inventory systems with retrials of unsatisfied customers. The time for producing and adding each item to the inventory is exponentially distributed with rate b. However, a production rate ab higher than b is used at the beginning of the production. The higher production rate will reduce customers’ loss when inventory level appro...

This paper investigates the simulation of a hybrid desalination system composed of multi-effect evaporation with thermal vapour compression desalination (METVC) and reverse osmosis (RO) plant. The hybrid desalination system is also integrated with a gas turbine power plant through a heat recovery steam generator (HRSG). First, a comprehensive Thermodynamic model for HRSG, METVC, and RO are deve...

The production costs reduction in a highly competitive environment is a critical success factor. In particular, in fields where outsourcing is used frequently and the impact of the material costs is high, a significant cost reduction can be achieved making more efficient value chain. Moreover, the use of outsourcing is a way to adjust production capacity depending on demand. Therefore the coord...