Sixty years ago, Steele, Richardson and Olszewski designated progressive supranuclear palsy (PSP) as a new clinicopathological entity in their seminal paper. Since then, in addition to the classic Richardson's syndrome (RS), different clinical phenotypic presentations have been linked with this four-repeat tauopathy. The clinical heterogeneity is associated with variability of regional distribu...

Progressive supranuclear palsy (PSP) was originally described in 1964. Although some contended it was merely a variant of Parkinson's disease, a specific electron microscopic finding of straight, rather than twisted, filaments in the neurofibrillary tangles established PSP as a distinct entity. The almost pathognomonic early clinical finding of paralysis of downward gaze is due to lesions invol...

BACKGROUND We aimed to investigate recall of autobiographical memories across lifetime periods in patients with progressive supranuclear palsy (PSP). METHOD Patients with PSP (n = 10) were given a test of autobiographical and personal semantic information and the Addenbrooke's Cognitive Examination (ACE). The result was compared to 30 matched neurologically intact participants. RESULT A mil...

Data relating to the stability and variation in the norms for the Raven's Progressive Matrices Test (a well-validated measure of basic cognitive functioning) for different cultural, ethnic, and socioeconomic groups on a worldwide and within-country basis are first summarized. Subsequent sections deal with variation over time. A possible explanation for the variation in norms over time and betwe...

The particle number projected BCS (PBCS) approximation is tested against the exact solution of the SO(5) Richardson-Gaudin model for isovector pairing in a system of nondegenerate single-particle orbits. Two isovector PBCS wave functions are considered. One is constructed as a single proton-neutron pair condensate; the other corresponds to a product of a neutron pair condensate and a proton pai...

Progressive supranuclear palsy is a progressive neurodegenerative disorder for which no specific treatment is known at present. In this report we treated a small group of clinically diagnosed patients with rapid-rate repetitive transcranial magnetic stimulation of the motor cortex for five days. This resulted in modest and transient improvements, especially of the axial symptomatology. Side-eff...

The practice shows that in everyday life we encounter ever-growing demand for better visual acuity at all viewing distances. The presbyopic population needs correction to far, near and intermediate distance with different dioptric powers. PAL lenses seem to be a comfortable solution. The object of the present study is the analysis of the factors determining adaptation to progressive addition le...

BACKGROUND Pure akinesia with gait freezing is a rare syndrome with few autopsied cases. Severe freezing of gait occurs in the absence of bradykinesia and rigidity. Most autopsies have revealed progressive supranuclear palsy. We report the clinical and postmortem findings of two patients with pure akinesia with gait freezing, provide video recordings of these patients, and review the literature...

We examined the topography and degree of cell loss within basal ganglia structures commonly involved in progressive supranuclear palsy in order to identify any relationship between degeneration in these nuclei and gaze palsy. Serial section analyses and unbiased quantitative techniques were applied to brain tissue from six cases with progressive supranuclear palsy (four with gaze palsy and two ...

BACKGROUND Differentiating movement disorders is critical for appropriate treatment, prognosis, and for clinical trials. In clinical trials this is especially important as effects can be diluted by inclusion of inappropriately diagnosed participants. In early disease duration phases, disorders often have overlapping clinical features, such as impairments in repetitive finger movement, making di...