currently, gastrointestinal (gi) dysfunctions in parkinson’s disease (pd) are well?recognized problems and are known to be the initial symptoms in the pathological process that eventually results in pd. many types of pd?associated gi dysfunctions have been identified, including weight loss, nausea, hypersalivation, dysphagia, dyspepsia, abdominal pain, intestinal pseudo?obstruction, constipatio...

Progressive supranuclear palsy (PSP) has been reported as a disorder mainly characterized by tendency to fall, vertical gaze palsy, and constriction of the body axis, akinesia, cognitive impairment. Patients presenting with these typical clinical features are diagnosed having PSP-Richardson syndrome (PSP-RS). Electronystagmography (ENG) is useful for detection ocular motility disorder, which ma...

In the Caribbean island of Guadeloupe, patients with atypical parkinsonism develop a progressive supranuclear palsy-like syndrome, named Guadeloupean parkinsonism. Unlike the classical forms of progressive supranuclear palsy, they develop hallucinations and myoclonus. As lesions associated with Guadeloupean parkinsonism are poorly characterized, it is not known to what extent they differ from p...

Three cases of progressive supranuclear palsy are reported in which In111-DTPA cisternography showed slow diffusion, ventricular reflux and failure of isotope clearance. The clinical diagnosis of progressive supranuclear palsy was confirmed histologically in two of these patients. The possible causes of the cisternographic changes and their relationship to the changes of CSF dynamics in progres...

BACKGROUND We hypothesized that postural instability and cognitive decline in patients with Richardson’s syndrome could be a consequence of reduced thalamic and frontal metabolism. Severe Parkinsonian signs in patients with progressive supranuclear palsy-parkinsonism may be reflected by alterations in putaminal metabolism. METHODS Eleven patients with Richardson’s syndrome, 8 patients with pr...

Progressive supranuclear palsy is characterised pathologically by the deposition of neurofibrillary tangles consisting of tau protein. Patients with the disease have been reported to have a more frequent occurrence of one allele of an intronic polymorphism of the tau gene. Other diseases which may involve tau deposition include frontotemporal dementia and corticobasal degeneration. This polymor...

OBJECTIVE We studied the annual change in measures of motor, oculomotor and cognitive function in progressive supranuclear palsy. This had twin objectives, to assess the potential for clinical parameters to monitor disease progression in clinical trials and to illuminate the progression of pathophysiology. METHODS Twenty three patients with progressive supranuclear palsy (Richardson's syndrom...

BACKGROUND AND PURPOSE The thalamus is interconnected with the nigrostriatal system and cerebral cortex and has a major role in cognitive function and sensorimotor integration. The purpose of this study was to determine how regional involvement of the thalamus differs among Parkinson disease, progressive supranuclear palsy, and corticobasal syndrome. MATERIALS AND METHODS Nine patients with P...