Factors that stimulate mitochondrial biogenesis in skeletal muscle include AMP-activated protein kinase (AMPK), calcium, and circulating free fatty acids (FFAs). Chronic treatment with either 5-aminoimidazole-4-carboxamide riboside (AICAR), a chemical activator of AMPK, or increasing circulating FFAs with a high-fat diet increases mitochondria in rat skeletal muscle. The purpose of this study w...

BACKGROUND Grip strength is widely used for estimating whole body strength but there is a lack of information relating to grip endurance. Comparison between endurance of different muscle groups has received little attention. The main aim of the present study was to determine the endurance characteristics of hand grip and quadriceps muscles in healthy young adults and then to examine the associa...

BACKGROUND The lower limb muscle strength is an important determinant of physical function in older people. However, measurement in clinical and epidemiological settings has been limited because of the requirement for large-scale equipment. A protocol using a novel, versatile hand-held dynamometer (HHD) has been developed to measure the quadriceps strength in a supine position. OBJECTIVE The ...

The activity of pyruvate dehydrogenase (PDHC), a key enzyme complex in the oxidative disposal of glucose, was measured after an oral glucose load in the heart, liver, quadriceps muscle, white adipose tissue (WAT) and brown adipose tissue (BAT) of gold-thioglucose (GTG)-obese mice at different stages during the development of obesity and in age-matched controls. Significant responses to the gluc...

An increased basal plasma lactate concentration is present in many physiological and pathological conditions, including obesity and diabetes. We previously demonstrated that acute lactate infusion in rats produced a decrease in overall glucose uptake. The present study was carried out to further investigate the effect of lactate on glucose transport and utilization in skeletal muscle. In chroni...

BACKGROUND There is very little by way of clinical examination that helps in the diagnosis of subtypes of limb-girdle muscular dystrophy (LGMD). A small observation led to this study on a clinical sign in a group of 31 patients with dysferlinopathy that included 13 with LGMD-2B and 18 with Miyoshi myopathy (MM). The patients were asked to stand with knees slightly bent so that the quadriceps mu...

Background: The present study examined the relationship between muscle strength and range of motion in the lower extremity, and balance and risk of falling in the elderly. Methods: This cross-sectional study was conducted on healthy elderly (mean±SD age: 65.64±4.95 y) in Rasht City, Iran. The study participants were 65 healthy male elderly who met the stud inclusion criteria. They were selecte...

We describe two cases of myofibrillar myopathies, due to different gene mutations. The first was a girl with cardiomyopathy and sensory axonal neuropathy that underwent cardiac transplantation at 15 years suffers from rotatory scoliosis BAG3 mutation. second is male patient, evident limb-girdle weakness since age 3. Two muscle biopsies were performed ages 3 15, MRI, LDB3 sequence analysis also ...

Knee injury rehabilitation often includes the step-up exercise. However, the authors have been unable to locate documentation of the effect of the step-up exercise on lower extremity strength indices. The purpose of this study was to determine the effect of a six-week lateral step-up exercise protocol on quadriceps muscle group strength. Twenty female nonetheless (age 20 ± 1.5 yrs, ht 162.6 ± 4...