Multi-socket server boards have emerged to increase the processing power density on the board level and further flatten the data center networks beyond leaf-spine architectures. Scaling however the number of processors per board puts current electronic technologies into challenge, as it requires high bandwidth interconnects and high throughput switches with increased number of ports that are cu...

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Multi shuttle automated storage retrieval systems have been developed for use in factories and distribution centers since they are more e cient than single shuttle systems due to less empty travel This improved e ciency results in more agile support exible response less waiting time etc for the production system the storage retrieval system serves In this paper we develop analytical models to e...

Bike sharing systems (BSSs) offer a mobility service whereby public bikes, located at different stations across an urban area, are available for shared use. An important point is that the distribution of rides between stations is not uniformly distributed and certain stations fill up or empty over time. These empty and full stations lead to demand for bikes and return boxes that cannot be fulfi...

Combinatorial chemistry and high-throughput screening have increased the possibility of finding new lead compounds at much shorter time periods than conventional medicinal chemistry. However, too much promising drug candidates often fail because of unsatisfactory ADME properties. In silico ADME studies are expected to reduce the risk of late-stage attrition of drug development and to optimize s...

This article may be used for research, teaching and private study purposes. Any substantial or systematic reproduction, redistribution , reselling , loan or sub-licensing, systematic supply or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to da...

This paper proposes a self-learning approach to determine optimal pricing strategies for high-occupancy/toll lane operations. The approach learns recursively motorists’ willingness to pay by mining the loop detector data, and then specifies toll rates to maximize the freeway’s throughput while ensuring a superior travel service to the users of the toll lanes. In determination of the tolls, a mu...

Using administrative data for high-priority calls in Calgary, Alberta, we estimate how ambulance travel times depend on distance. We find that a logarithmic transformation produces symmetric travel-time distributions with heavier tails than those of a normal distribution. Guided by non-parametric estimates of the median and coefficient of variation, we demonstrate that a previously proposed mod...