Introduction: Due to interesting therapeutic properties of 46Sc and antineoblastic antibiotic, bleomycin (BLM), 46Sc-bleomycin (46Sc-BLM) was developed as a possible therapeutic compound. Methods: In this work, Sc-46 chloride was obtained by thermal neutron flux (4 × 1013 n.cm-2.s-1) of natural metallic scandium sample followed ...

The phenol of 1-(3-(1H-imidazol-1-yl)propyl)-3-(4-hydroxy-3-methoxyphenyl)thiourea was selectively carbon-11 labelled to generate [11C]PBD150 in 7.3% yield from [11C]methyl triflate (non-decay corrected; radiochemical purity ≥95%, specific activity = 5.7 Ci/µmol, n=5). Evaluation of [11C]PBD150 by small animal PET imaging (mouse and rat) determined it does not permeate the blood brain barrier, ...

Ic,, is the concentration (pg of protein/ml) producing 50% inhibition of the biosynthesis of each prostaglandin as measured by the radiochemical method described in the text. Human serum (freeze-dried) and plure plasma albumin (Cohn fraction V) were obtained from Miles Laboratories. Haptoglobin was purified from Cohn fraction IV-4 to 76% purity by the method of Saeed et al. (1980). NT, not test...

6-Deoxy-6-[(18)F]fluoro-D-fructose (6-[(18)F]FDF) is a promising PET radiotracer for imaging GLUT5 in breast cancer. The present work describes GMP synthesis of 6-[(18)F]FDF in an automated synthesis unit (ASU) and dosimetry calculations to determine radiation doses in humans. GMP synthesis and dosimetry calculations are important prerequisites for first-in-human clinical studies of 6-[(18)F]FD...

somatostatin analoges labeled with different radionuclides are able used for imaging and treatment of somatostatin receptor positive tumors. in this study tyr³-octreotide protected at lysine as an analoge of somatostatin was conjugated with bifunctional chelating agent 6-boc-hydrazinopyridine-3-carboxylic acid (boc-hynic) and after deprotecting of conjugate, purification was performed with prep...

Maturing seeds of Sinapis alba were incubated with D-[U-14C]glucose, sodium [l-14C]acetate or m>>0-[U-14C]inositol in order to prepare radioactively labelled phytic acid with high specific activity. Although each substrate was utilized for the biosynthesis of phytic acid, maximum incorporation of radioactivity into phytic acid was found with rayo-inositol. Radiochemical purity of the [U-14C]phy...

Cu]-N-(2-hydroxyacetophenone)glycinate ([Cu]NHAG) was prepared using in house-made NHAG ligand and [Cu]CuCl2 produced via the Zn(p,x)Cu (180μA proton irradiation, 22MeV, 3.2h) and purified by a ion chromatography method. [Cu]NHAG radiochemical purity was >98% and >99.9% by RTLC and HPLC methods respectively after purification by SPE. [Cu]NHAG was administered into normal and tumor bearing mice ...

Received 9/4/2000; revised 9/29/2000; accepted 10/31/2000. For correspondence or reprints contact: Wei-Jen Shih, M.D., Nuclear Medicine Service, Lexington VA Medical Center, Lexington, KY40511, U.S.A. Tel: (859)-3815928, Fax: (859)-3815934 E-mail: [email protected] Interpretation of a brain SPECT using Tc labeled cerebral perfusion imaging agent such as Tc-ECD requires high uptake of the trace...

[61Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([61Cu] ATSM) was prepared using in house-made diacetyl-bis(N4-methylthiosemicarbazone) (ATSM) ligand and [61Cu]CuCl2 produced via the natZn(p, x)61Cu (180 muA proton irradiation, 22 MeV, 3.2 h) and purified by a ion chromatography method. [61Cu]ATSM radiochemical purity was >98 %, as shown by HPLC and RTLC methods. [61Cu]ATSM was administered into...