PURPOSE We have previously shown that zebrafish (Danio rerio) embryos can be used as an in vivo model to validate modifiers of the radiation response. Here, we evaluated the radioprotective effect of the nanoparticle DF-1, a fullerene with antioxidant properties, in zebrafish embryos. EXPERIMENTAL DESIGN Zebrafish embryos were exposed to different doses of ionizing radiation ranging from 20 t...

Radiation is an important source of free radicals in living systems. Ionizing radiations such as γ-rays exert their biological effects through generation of reactive oxygen species and the resultant damage to DNA and cellular membranes. Several natural compounds, especially with antioxidant abilities are known to be radioprotective. Baicalein (5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one), a...

Manganese porphyrins have been shown to be potent radioprotectors in a variety of cancer models. However, the mechanism as to how these porphyrins protect normal tissues from radiation damage still remains largely unknown. In the current study, we determine the effects of the manganese porphyrin, MnTnBuOE-2-PyP, on primary colorectal fibroblasts exposed to irradiation. We found that 2 Gy of rad...

*Corresponding author: Dr. Zhong-Li Gao, Department of Orthopaedics, China-Japan Union Hospital of Jilin University, #126 Xiantai Street, Changchun City, Jilin Province, P.R. China, 130033. Fax: +860 43 184611598 E-mail: [email protected] Background: Microwave Thermotherapy has been gradually used in radiotherapy and it is reported that microwave radiation increases bone demineralization ...

background: microwave thermotherapy has been gradually used in radiotherapy and it is reported that microwave radiation increases bone demineralization rate independently of temperature. furthermore, it becomes more and more widespread that the damage caused by the synergistic effect of microwave radiation and hypergravity. the experiment was designed to investigate the effect of microwave radi...

background: exposure to ionizing radiation results in genotoxicity and the unrepaired lesions in cellular dna results in cell cycle arrest, reproductive death, interphase death, division delay, chromosome aberrations, mutations, etc. leading to the intensive destruction of cells and violation of their proliferative capacity there by adversely affecting the mammalian system. since ionizing radia...

Normal skin is composed of epidermis and dermis. Skin is susceptible to radiation damage because it is a continuously renewing organ containing rapidly proliferating mature cells. Radiation burn is a damage to the skin or other biological tissues caused by exposure to radiofrequency energy or ionizing radiation. Acute skin reaction is the most frequently occurring side effect of radiation thera...

Background: Ionizing radiation induces the production of reactive oxygen species (ROS), which play an important causative role in cell death. Wholebody exposure of mice to gamma radiation leads to diminution of tissue antioxidant defense systems increases the peroxidative damage to membrane lipids and damages the haematopoietic and gastrointestinal systems. Tempol (TPL), a cell membranep...

normal skin is composed of epidermis and dermis. skin is susceptible to radiation damage because it is a continuously renewing organ containing rapidly proliferating mature cells. radiation burn is a damage to the skin or other biological tissues caused by exposure to radiofrequency energy or ionizing radiation. acute skin reaction is the most frequently occurring side effect of radiation thera...

Background: Exposure to ionizing radiation results in genotoxicity and the unrepaired lesions in cellular DNA results in cell cycle arrest, reproductive death, interphase death, division delay, chromosome aberrations, mutations, etc. leading to the intensive destruction of cells and violation of their proliferative capacity there by adversely affecting the mammalian system. Since ionizing radia...