Ionizing radiation transfuses deleterious effects in biological systems. Radiation exposures could be accidental or intended. Efforts for the development of a safe radioprotector have been going over many decades. Several chemical and synthetic compounds have been evaluated to meet the need, however, associated toxicity with useful doses has precluded their use from bench to bed. Presence of nu...

results histopathologically, a decrease (statistically not significant) in the thickening of alveolar or bronchial wall, formation of fibrous bands, and superimposed collagen were noted in the animals in group b as compared to the animals in group a. conclusion in this experimental study, administration of gla one hour before thoracic irradiation may be a protective agent against radiation-indu...

AIM To investigate the survival of laboratory rats after irradiation and to study the cellularity of their bone marrow and the multipotential mesenchymal stem cells (BM-MSCs) in groups treated with or without a new thiol-based radioprotector (GM2011). METHODS Animals were irradiated by a Cobalt gamma source at 6.7 Gy. Treated animals were given i.p. GM2011 30 minutes before and 3 and 7 hours ...

background: oxidative stress plays an important role in the pathogenesis and progression of γ-irradiation-induced cellular damage, lung is a radiosensitive organ and its damage is a dose-limiting factor in radiotherapy. the administration of dietary antioxidants has been suggested to protect against the succeeding tissue damage. the present study aimed to evaluate the radioprotective efficacy o...

Background. Apart from surgery and medications, radiation therapy is one of the main treatment methods for malignant tumors cervix. However, its use associated with high incidence urological complications. In addition, need long-term treatment, reduced level patients’ quality life promote necessity to minimize frequency complications justify search study most adequate their prevention. Aim. To ...

Disulfiram/Radioprotector/Comet assay/Lipid peroxidation. Disufiram (a drug used for the treatment of alcoholism) protected microsomal membranes and plasmid DNA against damages induced by gamma-radiation. The peroxidation of membrane lipids increased linearly with the radiation dose up to 600 Gy, and the presence of disulfiram inhibited membrane lipid peroxidation as assayed by the presence of ...

The article by Drs. Wasserman and Brizel concludes that protection of normal tissue from side effects due to radiotherapy will permit dose escalation and improve therapeutic efficacy and treatment outcomes. Although this concept is sound in principle, its generalized clinical application hinges critically on two controversial issues associated with the use of all putative radioprotective agents...

Silymarin, a purified extract of seeds of Silybum marianum L. and well known for its hepatoprotective abilities, has been evaluated for inherent utility as a radioprotective agent. A fraction (INM-7035) was authenticated by characterizing the percentage composition of silybin A and B (39.9% and 57.4%). Free radical scavenging activities of INM-7035 against superoxide radicals (>68%), hydroxyl r...