background: dna isolation procedure can significantly influence the quantification of dna by real time pcr specially when cell free dna (cfdna) is the subject. to assess the extraction efficiency, linearity of the extraction yield, presence of co-purified inhibitors and to avoid problems with fragment size relevant to cfdna, development of appropriate external dna control (edc) is challenging. ...

We aimed to examine the extent to which inaccurate assumptions for nuisance parameters used to calculate sample size can affect the power of a randomized controlled trial (RCT). In a simulation study, we separately considered an RCT with continuous, dichotomous or time-to-event outcomes, with associated nuisance parameters of standard deviation, success rate in the control group and survival ra...

We study systems with several components which are subject to different types of failures. Examples of such systems include twin engines of an airplane or the paired organs in a human body. We find that such a system, using conditional arguments, can be characterized as multivariate geometric distributions. We prove that the characterizations of the geometric model can be achieved using conditi...

Motion tracking is one of the most practical applications of computer vision in real life. In this paper, we highlight a new application for tracking motion and estimating the velocity of the moving vehicle in terms of clustering of optical flows. A centroid neural network with a metric utilizing optical flow is employed to group pixels of moving vehicles from traffic images, and to generate bl...

Abstract: Many estimation methods have been proposed for the parameters of statistical distribution. The least squares estimation method, based on a regression model or probability plot, is frequently used by practitioners since its implementation procedure is extremely simple in complete and censoring data cases. However, in the procedure, heteroscedasticity is present in the used regression m...

Thorough QT studies are becoming a necessary part of the clinical profile of existing and investigational new drugs. The E14 guidelines mandate performing a thorough QT study on any non antiarrythmic drug to ensure that the drug does not produce a QT prolongation effect before it can be approved and marketed. The cost involved in running a thorough QT study is substantial and an adverse outcome...

The final approach phase of spacecraft rendezvous and docking is extremely important. In order to solve the problem of the real-time acquisition of the relative pose between target and spacecraft in near distance (<2m), this paper established a binocular stereovision model, and proposed a non-cooperative target relative pose measuring method based on stereo vision and RANSAC algorithm. Linear c...

A prospective hospital-based study was undertaken to define the incidence of invasive pneumococcal disease (IPD) and circulating serotypes in Laos. Of 10,799 patients with hemocultures and 353 patients with cerebrospinal fluid samples, 0.21% and 5.4%, respectively, were positive for Streptococcus pneumoniae, giving a total of 35 IPD patients. We developed a real-time polymerase chain reaction t...