We previously reported that amino acids 20 to 50 of nuclear receptor interacting factor-3 mediates rapid apoptosis in breast cancer cell lines but not in cells derived from other tissues. We refer to this short region as death domain-1 (DD1). Small interfering RNA studies indicated that DD1-mediated apoptosis is caspase-2 dependent. In this study, we examined DD1-mediated apoptosis in more deta...

results isotype of 1f1 clone was determined to be igg1, which reacted with native protein in the western blot experiment and stained 20% of the membrane of neoplastic cells overexpressing her2 with 3+ grade. however, 3l5 clone showed a low reaction (10%) with native her2 in immunohistochemistry. conclusions the results of both western blotting and immunohistochemistry showed that native her2 ca...

Background: Breast cancer is a malignant proliferation of epithelial cells that lining the ducts or lobules of the breast. Breast cancer is the second common cancer (after lung cancer) in women. Gallic acid, being a polyphenols, has been reported for its antiproliferative activity against many cancer cell lines. Objective of the present study is effect of gallic acid on proliferation and apopto...

curcumin exhibits both cancer- preventive activity and growth inhibitory effects on several neoplastic cells including human colon cancer. serotonin and its receptors have also been implicated in tumor development. this study investigated the effect of ritanserin, a selective serotonin 5ht2a receptor antagonist, alone and in combination with curcumin on colorectal cancer cell lines. results sho...

Slit regulates migration of not only neurons, but also nonneuronal cells, such as leukocytes and cancer cells. Slit effect on cancer cell migration has not been well-characterized. In this study, we used several different assays to examine Slit effect on breast cancer cell migration in vitro. We show that ubiquitin-specific protease 33 (USP33)/VDU1, originally identified as a von Hippel-Lindau ...

Background: Breast cancer is an important cause of cancer death among women all over the world. Even in places with low incidence there are reports of an increase in the number of breast cancer patients. The aim of the present study was to report the demographic aspects of breast cancer among patients referred by surgeons for adjuvant therapy in a private cancer clinic during the past five year...

Abstract Targeting cancer stem cells (CSC) can serve as an effective approach toward limiting resistance to therapies. While basal-like (triple-negative) breast cancers encompass with CSC features, rational therapies remain poorly established. We show here that the receptor tyrosine kinase Met promotes YAP activity in and find enhanced within population. Interfering delayed formation, prevented...

The fetal isoform A of the insulin receptor (IR-A) is frequently overexpressed in a variety of malignancies including breast cancer. IR overexpression has a recognized role in cancer progression and resistance to anticancer therapies. In particular, IR-A has a peculiar mitogenic potential and is activated not only by insulin but also by IGF-2. Previously, we identified discoidin domain receptor...

the two stable isotopes of hydrogen, protium (1h) and deuterium (2h) differ in their physicochemical nature. deuterium-depleted water (ddw) significantly inhibited the growth rate of different tumor cell lines in culture media and xenotransplanted mda-mb-231, mcf-7 human breast adenocarcinomas and pc-3 human prostate tumors in vivo. the apoptosis-triggering effect of ddw was demonstrated both i...