OBJECTIVES To characterize the distribution of linezolid in lung when it accesses this organ from the systemic circulation and when administered through the pulmonary route and to evaluate the influence of the 'respiratory mode' in the pulmonary distribution for both routes. METHODS The study was conducted with 24 Wistar rats divided into four groups treated with linezolid under different exp...

Paraesophageal hiatus hernia (PEHH) is an uncommon type of diaphragmatic hernia in the pediatric age group. Two patients aged 5-months and 8-months presented with respiratory symptoms and underwent a laparoscopic repair. Preoperative assessment included chest x-ray and CT scan. We suggest that laparoscopic repair of PEHH in infants is safe and preferred mode of the treatment.

Ventilatory patterns and respiratory timing were measured in 14 subjects during cycling (CYC) and treadmill exercise (TM) at similar leg frequencies (fLEG) to determine if mode of exercise affects patterns of ventilation and respiratory timing. Measurements of breathing frequency (fR), tidal volume (VT), expired ventilation (VE), and inspiratory (TI) and expiratory (TE) time were obtained at fL...

BACKGROUND Noninvasive positive-pressure ventilation (NPPV) unloads respiratory muscles. Spontaneous-breathing ventilation modes require patient effort to trigger the ventilator, whereas controlled modes potentially economize on patient triggering effort and thus achieve more complete respiratory muscle rest. Data on controlled NPPV have not been published to date. We hypothesize that controlle...

The purpose of this study was to examine whether tongue pressure on the lingual surface of the mandibular incisors shows respiratory-related changes, with particular attention paid to its relationship to genioglossus electromyographic activity, and to determine the effect of changes in the mode of breathing and body position on tongue pressure. Tongue pressure was recorded with a miniature pres...

This paper presents a two-stage crackle detection algorithm combining Empirical Mode Decomposition (EMD) and a simple energy peak detector. A discussion is presented of the main issues arising in the implementation of the EMD stage and the solutions adopted. The algorithm was implemented in MATLAB® and preliminarily tested on an annotated 10-second respiratory sound file, without any prior syst...

Background: Application noninvasive ventilation in the patients with exacerbation of chronic obstructive pulmonary disease (COPD) reduced mortality. This case-control study was designed to compare efficiency and outcome of non-invasive (NIV) versus invasive positive pressure ventilation (IPPV) in respiratory failure due to COPD Methods: The patients were assigned to NIV or IPPV intermittantl...

Ventilators functions and features have evolved with the advancement of technology along addition microprocessors. It is important to understand examine benefits risks associated these advanced automated modes. Adaptive Support Ventilation (ASV) a mode that unique Hamilton Medical ventilators, thereby limiting number clinicians who experience using this mode. ASV can make changes respiratory ra...

Acute respiratory distress syndrome (ARDS) results in collapse of alveoli and therefore poor oxygenation. In this article, we review airway pressure release ventilation (APRV), a mode of mechanical ventilation that may be useful when, owing to ARDS, areas of the lungs are collapsed and need to be reinflated ("recruited"), avoiding cyclic alveolar collapse and reopening.