Ann Rheum Dis March 2010 Vol 69 No 3 473 1Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada 2Erasmus Medical Centre, University of Rotterdam, Rotterdam, The Netherlands Correspondence to: Dr Vivian P Bykerk, Mount Sinai, 75 Francis Street, PBB-B3, Boston, MA 02115, USA; [email protected] When does rheumatoid arthritis start and can it be stopped before it does? Vivian P B...

Seasonal adjustment methods transform observed time series data into estimated data, where these estimated data are constructed such that they show no or almost no seasonal variation. An advantage of model-based methods is that these can provide con dence intervals around the seasonally adjusted data. One particularly useful time series model for seasonal adjustment is the basic structural time...

editorial board G. Agnelli, Perugia, Italy J.T. van Dissel, Leiden, the Netherlands R.O.B. Gans, Groningen, the Netherlands A.R.J. Girbes, Amsterdam, the Netherlands D.E. Grobbee, Utrecht, the Netherlands E. de Jonge, Leiden, the Netherlands D.L. Kastner, Bethesda, USA M.H. Kramer, Amsterdam, the Netherlands E.J. Kuipers, Rotterdam, the Netherlands Ph. Mackowiak, Baltimore, USA J.W.M. van der M...

The Rhine River Delta is crucial to the Dutch economy. The Maeslant barrier was built in 1997 to protect the Rhine estuary, with the city and port of Rotterdam, from storm surges. This research takes a simple approach to quantify the influence of the Maeslant storm surge barrier on design water levels behind the barrier. The dikes in the area are supposed to be able to withstand these levels. E...

OBJECTIVE SIRT1 has pleiotropic metabolic functions. We investigated whether SIRT1 genetic variation is associated with obesity. RESEARCH DESIGN AND METHODS In 6,251 elderly subjects from the prospective, population-based Rotterdam Study, three single nucleotide polymorphisms (SNPs) in the SIRT1 gene were studied in relation to BMI and risk of obesity (BMI > or =30 kg/m(2)) and prospectively ...

The separability of consumer desires is a necessary and sufficient condition for multi-stage budgeting and Collectivization is consistent of commodity where costs are allocated between edible groups using price indices and intergroup allocations are made independently of other groups. Given the high share of Citrus fruits, Cucurbits and vegetables types (29/5% percent of household food and beve...

The use of the radial artery as preferred access site for coronary diagnostics and interventions is rapidly increasing worldwide given the extensive evidence demonstrating its benefit on vascular complications and mortality, its costeffectiveness, and the increased patient satisfaction in comparison with the femoral approach. However, this approach could be complicated by radial artery occlusio...

A number of recent theoretical studies have explored trading in fragmented markets, e.g. Biais et al. (2000), a phenomenon increasingly witnessed in modern markets. The key assumption generating the results is that there is at least one liquidity demander exploiting access to all markets by optimally splitting orders across markets. This paper seeks to test this assumption in a natural experime...

BACKGROUND Since mortality in congenital diaphragmatic hernia (CDH) is decreasing, morbidity such as neurodevelopmental outcome is becoming increasingly important. OBJECTIVES We evaluated neurodevelopmental outcome in high-risk CDH patients treated according to the CDH EURO Consortium standardized treatment protocol. METHODS This observational, prospective cohort study was conducted in two ...

1.2 Diagnostic criteria The condition was described by Stein and Leventhal in 1935. There is a considerable controversy on the optimal criteria for PCOS. Although the NIH (National Institute of Health) criteria as hyperandrogenic anovulatory PCOS were proposed in 1992, these have now expanded to non NIH criteria including hyperandrogenic ovulatory to nonhyperandrogenic anovulatory PCOS (2). Aft...