BACKGROUND There is a lack of basic knowledge on the part of both clinicians and patients as to the indications for use and safety of herbal medicines used in pregnancy and lactation. This is one article in a series that systematically reviews the evidence for commonly used herbs during pregnancy and lactation. OBJECTIVES To systematically review the literature for evidence on the use, safety...

We discuss some aspects of recent research as well as more general issues about motivation, useful methods and open problems in the field of cosmological singularities. In particular, we review some of the approaches to the general area and include discussions of the method of asymptotic splittings, singularity and completeness theorems and the use of the Bel-Robinson energy to prove completene...

Foreknowledge of demand is useful in the control of a production-inventory system. Knowing the customer orders in advance makes it possible to anticipate properly. It is an important condition to produce and deliver the right quantity of the right product “just-in-time”. It reduces the need of safety stock and spare capacity. But the question of the effectiveness of foreknowledge is not an easy...

In a one parameter family of dilaton gravity theories which allow the coupling of the dilaton to gravity and to a U(1) gauge field to differ, we have found the existence of everywhere regular spacetimes describing black holes hiding expanding universes inside their horizon.

For the multivariate one-sample location model (relating to a diagonally symmetric distribution). sequential non-parametric (point as well as interval) estimators based on appropriate rank statistics are considered and their asymptotic properties studied. In this context. asymptotic risk-efficiency of the proposed estimators and asymptotic normality of the associated stopping times are establis...

Over-the-counter (OTC) medications are among the most commonly used products in pregnancy. Similar to prescription medications, for many products there is a lack of adequate data on safety of use in pregnancy. Assumptions of safety for these products based on long experience and OTC status, in the absence of data, may be ill founded. Examples of four OTC products used to treat common conditions...

We encountered a case of severe acute respiratory distress syndrome in late pregnancy due to influenza (H1N1) with refractory hypoxemia to conventional mechanical ventilation. Ventilation in prone position rescued this patient by maintaining oxygenation and sustaining improvement thereafter. Here, we discuss the mechanism of prone ventilation with special references to safety management of acut...

Objective: The possible toxicity of drugs in pregnancy should be tested before their use in pregnant patients. In the present study, we aimed to evaluate the safety of phytovagex, a pessary formulation of Nigella sativa (N. sativa), which is already in clinical use for vaginal fungal infection. Materials and Methods: The pregnant rats were treated intravaginal with physiological saline (vehicle...

Malaria in pregnancy (MiP) is a major, preventable cause of maternal morbidity and poor birth outcomes. To prevent the adverse outcomes of MiP, WHO recommends the use of insecticidetreated mosquito nets (ITNs), and effective case management of malaria and anaemia in pregnant women. In areas of moderate to high malaria transmission of sub-Saharan Africa, WHO also recommends intermittent preventi...