BACKGROUND Hepcidin, a key regulator of iron metabolism, is synthesized by the liver. Hepcidin binds to the iron exporter ferroportin to regulate the release of iron into plasma from macrophages, hepatocytes, and enterocytes. AIM To study hepcidin expression in liver tissue of patients with hepatocellular carcinoma (HCC), chronic hepatitis C (CHC) and normal human liver biopsies and to compar...

Background: Patients with transfusional iron overload have depended on iron chelation therapy and improving chelation regimens have been of the highest priority. The aim of this study was to compare effect of combined versus monotherapy with Deferoxamine (DFO) and Deferiprone (DFP) in iron overloaded beta thalassemia (BT) major patients Materials and Methods We studied 36 BT major patients (mea...

The aim of the present study was to analyze brain and body iron levels among patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and normal controls (NCs). A total of 90 participants (30 MCI, 30 AD, 30 NC) were enrolled. Brain iron content was quantified using susceptibility weighted imaging (SWI). Phase values were used to calculate bilateral iron content in the hippocampu...

objective: breath holding spells, very often misinterpreted as epileptic seizures, are most common in children aged 6 months to 6 years of age. in this investigation, we sought to prospectively document the natural history of breath holding spells (bhs) among children with cyanotic, pallid and mixed type bhs referred for neurological consultation. materials & methods: this was a cross-sectional...

OBJECTIVE Malabsorption is one of the causes of iron deficiency anemia in postmenopausal women. The main objective of this study was to access the frequency of malabsorption in iron deficient anemic postmenopausal women. METHODS A total of 123 postmenopausal women were enrolled in the study. Of these 123 women, 50 were included as 'control group' and 73 patients with comparable severity of an...

BACKGROUND Children participating in the Integrated Child Development Service (ICDS) in India have high rates of iron and vitamin A deficiency. OBJECTIVE The objective was to assess the efficacy of a premix fortified with iron and vitamin A and added at the community level to prepared khichdi, a rice and dal mixture, in increasing iron and vitamin A stores and decreasing the prevalence of iro...

Patients with alcoholic liver disease (ALD) often display disturbed iron indices. Hepcidin, a key regulator of iron metabolism, has been shown to be down-regulated by alcohol in cell lines and animal models. This down-regulation led to increased duodenal iron transport and absorption in animals. In this study, we investigated gene expression of duodenal iron transport molecules and hepcidin in ...

OBJECTIVE To evaluate the association between body iron stores, dietary iron intake, and risk of diabetes in northern China. RESEARCH DESIGN AND METHODS The data of a cross-sectional household survey in 2002 in Liaoning Province in northern China was used. The final sample in our study contained 2,997 subjects aged >or=18 years. Fasting plasma glucose and serum ferritin were measured. Dietary...

Background: Iron deficiency anemia is one of the most prevalent anemia in children and pregnant women in the world. It has recently been revealed that H.pylori infection is one the most important causes of anemia. Materials and Methods: In this analytical study 100 anemic children were analyzed using total Iron, Ferritin, TIBC and H.pylori IgG assay. Data were collected using a questionnaire in...