Many fungal adhesins have short, β-aggregation-prone sequences that play important functional roles, and in the Candida albicans adhesin Als5p, these sequences cluster the adhesins after exposure to shear force. Here, we report that Saccharomyces cerevisiae flocculins Flo11p and Flo1p have similar β-aggregation-prone sequences and are similarly stimulated by shear force, despite being nonhomolo...

Results from a wind tunnel model of the sheared atmospheric convective boundary layer (CBL) are presented and discussed. The model is realized in the thermally stratified wind tunnel of the Institute of Hydrology and Water Resources Planning (IHW), University of Karlsruhe. Design of the wind tunnel, and the technique employed for velocity and temperature measurements are described. The performe...

Acoustic stimulation is a promising method for increasing drainage of non-Newtonian fluids through porous structures in various applications. In this study, a mathematical model is developed for unsteady flow of a bi-viscous incompressible fluid in a circular straight channel. Longitudinal vibrations are superimposed on the flow driven by changing pressure gradients along the channel. Simulatio...

Shear-induced platelet aggregation (SIPA) involves von Willebrand Factor (vWF) binding to platelet glycoprotein (GP)Ib at high shear stress, followed by the activation of alphaIIb beta3. The purpose of this study was to determine the vWF sequences involved in SIPA by using monoclonal antibodies (MoAbs) to vWF known to interfere with its binding to GPIb and to alphaIIb beta3. Washed platelets we...

in reinforced concrete design, there are situations where transfer of shear across a specific plane needs to be considered. examples of such situation include corbels, bearing shoes, ledger beam bearing, and a host of connection between precast concrete elements. in this study, the shear transfer behavior of reinforced concrete is investigated experimentally by conducting test on 6 precracked p...

BACKGROUND AND OBJECTIVES Rheological evaluation of thermoreversible mucoadhesive nasal gel of zolmitriptan is done to determine the steady shear behaviour and gelation temperature. The thermoreversible mucoadhesive polymers are sucessesfully used to increase the contact time of the therapeutic compound in the nasal cavity as well as they cause enhancement in permeation of drug through the nasa...

The role of chronic fluid shear stress on endothelial constitutive nitric oxide synthase (cNOS) levels may have an important role in vessel diameter control. We subjected primary human umbilical vein endothelial cells (HUVEC) or bovine aortic endothelial cells (BAEC, passages 2-14) to steady laminar shear stress. In both cell types, the intracellular level of cNOS was elevated within 3 h of flo...