background & aim: deanaie thyme (thymus daenensis celak.), a member of the lamiaceae family.  thymus in one of the most important medicinal and aromatic plants that was used in pharmaceutical, food, cosmetics hygienic industries in most of developed countries. recent studies have showed that thyme have strong antibacterial, antifungal, spasmolytic and antioxidant activities. experimental: ...

A 52-year-old man complaining of persistent recurring chest pain at night underwent coronary angiogram at another institution. Normal coronaries were observed and he was discharged with muscle spasmolytic prescription. Since symptoms had continued, 24-hour Holter monitoring was ordered at our facility and results revealed huge ST elevation and polymorphic ventricular tachycardia. Cold pressor t...

Guava (Psidium guajava Linn.) Family Myrtaceae is important plant used traditionally for medicinal purposes. Guava is rich in antioxidants compounds and contains a high level of ascorbic acid. The pharmacological actions and the medicinal uses of aqueous extracts of guava leaves in folk medicine include the treatment of various type of gastrointestinal disturbances such as vomiting, diarrhea, i...

Hyoscine-N-butyl bromide is a widely used antispasmodic belonging to the belladonna alkaloid class of semisynthetic quaternary ammonium compounds. These compounds exert a spasmolytic action on the smooth muscles of the bile-gastrointestinal tract, genitourinary tract, salivary glands (xerostomia), and also on the visual apparatus - in particular, the irido-ciliary complex. As a consequence, the...

Objective: Several studies have shown the antispasmodic activity of Matricariarecutita without detailing the underlying mechanism(s). The present study was designed to determine whether the antispasmodic mechanisms of M. recutita extract mediated via histaminergic/cholinergic receptors, Ca2+channels, activation of PKA2 and NO release in isolated rabbit jejunum. Methods and Materials: The concen...

In its FDA approved formulation, N-butylscopolammonium bromide (Buscopan Injectable Solution, Boehringer Ingelheim Vetmedica) is an anticholinergic spasmolytic agent indicated for management of abdominal pain associated with spasmodic colic, flatulent colic, and simple impactions in horses. Use of this drug ablates gastrointestinal peristalsis and rectal pressure. It ahs been suggested that N-b...

Background/Aim. Phytochemical and pharmacological investigations of essential oils isolated from plant species the genus Seseli have been intensified recently. These long-term use in nutrition traditional medicine treatment various disorders. Volatile secondary metabolites gracile Waldst. & Kit (Apiaceae) not pharmacologically examined so far. The aim conducted research was to assess antira...

hydroalcoholic extract of pycnocycla spinosa has spasmolytic action in vitro . at oral dose of 250 m g/kg it inhibits castor oil induced diarrhea in mice. if p. spinosa extract has no serious adverse effect, it would be a good alternative medicine for treatment of diarrhoea and abdominal spasm. in this research, overall systemic effect of p. spinosa extract on mice behavior and reaction was inv...