Introduction: Stimuli-responsive hydrogels, which indicate a significant response to the environmental change (e.g., pH, temperature, light, …), have potential applications for tissue engineering, drug delivery systems, cell therapy, artificial muscles, biosensors, etc. Among the temperature-responsive materials, poly (N-isopropylacrylamide) (PNIPAAm) based hydrogels have been widely developed ...

Stimuli-responsive polymers as drug delivery vehicles have generated remarkable interest among polymer researchers during the last decade. In present work, we report synthesis of a new water soluble pH- and thermo-responsive biocompatible block copolymer containing phenylalanine derivatives. The formed micelle-like self-assembled nanoparticles above critical aggregation concentration, confirmed...

The emergence of heterogeneous photocatalysis has facilitated redox reactions with high efficiency, without compromising the recyclability photocatalyst. Recently, stimuli-responsive photocatalytic materials have emerged as a powerful synthetic tool, simple and rapid recovery, well an enhanced dynamic control over reactions. Stimuli-responsive polymers are often inexpensive easy to produce. The...

Polymer-drug conjugates are becoming established as a shining platform for drug delivery. Incorporation of pH-responsive linker between drug and polymer is expected to realize triggered release of bioactive agents from conjugates in specific sites, either in mildly acidic extracellular matrices of tumor tissues or, after cellular internalization, in acidic endosomes and lysosomes. As an emergin...

In recent years, multifunctional nanoparticles have received considerable attention in many applications such as biosensors, diagnostic nanoprobes, and targeted drug delivery. These efforts have been driven to a large extent by the need to improve biological specificity in diagnosis and therapy through the precise spatiotemporal control of agent delivery. To achieve this goal, continuous effort...

Objective(s): Development of an oral sustained-controlled release vehicle which, slowly releases the drug and maintains an effective drug concentration for a long time is aimed.Materials and Methods: A biodegradable magnetic polymeric drug delivery vehicle, using superparamagnetic iron oxide nanoparticles encapsulating by polyvinylpyrrolidone-block-polyethylene glycol-block-poly methacrylic aci...

Physicochemical properties, including particle size, zeta potential, and drug release behavior, affect targeting efficiency, cellular uptake, and antitumor effect of nanocarriers in a formulated drug-delivery system. In this study, a novel stepwise pH-responsive nanodrug delivery system was developed to efficiently deliver and significantly promote the therapeutic effect of doxorubicin (DOX). T...