zn (ii) is an important regulator of caspase-3, as well as an antioxidant, microtubule stabilizer, growth cofactor, and anti-inflammatory agent. over the past 30 years, many researchers have demonstrated the important role of zn (ii) in a variety of physiological processes, including growth and development, maintenance and priming of the immune system, and in tissue repair and regeneration. in ...

we investigated the effects of 25 mg-porphyrin-fullerene nanoparticles, ( 25 mgpmc16) smart ferroporphyrin nanoparticles, on pc12 cells exposed to oxygen-glucose deprivation/reperfusion. in order to explore its effect on cells under oxygen-glucose deprivation conditions, the cultures were pretreated with 25 mgpmc16 24 hours prior to oxygen-glucose deprivation/reperfusion. to initiate the oxygen...

objective(s) this study was carried out in order to evaluate the effects of electrochemotherapy, electrical pulses and chemotherapeutic drugs on the killing of cancerous cells and their probable synergistic effects. materials and methods electrochemotherapy treatments conducted on mcf-7 cell line derived from human breast adenocarcinoma tumor using four chemotherapeutic drugs including bleomyci...

BACKGROUND Angiogenesis, the process of new vessels generation, plays a critical role in tumor invasion and metastasis. Vascular Endothelial Growth Factor (VEGF), as a cytokine, and Matrix Metalloproteinases (MMPs), has been the important factors that involved in angiogenesis. Lipopolysaccharide (LPS) has an essential effect on angiogenesis. OBJECTIVES In this study the effect of LPS on VEGF ...

Mesenchymal stem cells (MSCs) have been shown to secrete exosomes that are cardioprotective. Here, we demonstrated that MSC exosome, a secreted membrane vesicle, is immunologically active. MSC exosomes induced polymyxin-resistant, MYD88-dependent secreted embryonic alkaline phosphatase (SEAP) expression in a THP1-Xblue, a THP-1 reporter cell line with an NFκB-SEAP reporter gene. In contrast to ...

Transcription-export complex 2 (TREX-2, or THSC) facilitates localization of actively transcribing genes such as GAL1 to the nuclear periphery, contributes to the generation of export-competent mRNPs and influences gene expression through interactions with Mediator. TREX-2 is based on a Sac3 scaffold to which Thp1, Sem1, Cdc31 and Sus1 bind and consists of three modules: the N-region (Sac3∼1-10...

Suspension cultures of a human monocytic leukemia cell line, THP-1, were treated with 0.16 to 160 nw 12-O-tetradecanoylphorbol-13-acetate (TPA). In an original cell line, THP1-O, cultured again from —80°cryopreservation, more than 80% of the cells adhered to the glass substrate with marked morphological change within 3 hr of TPA treatment. Adherent cells became flat and amoeboid in shape, an...

Suspension cultures of a human monocytic leukemia cell line, THP-1, were treated with 0.16 to 160 nw 12-O-tetradecanoylphorbol-13-acetate (TPA). In an original cell line, THP1-O, cultured again from —80°cryopreservation, more than 80% of the cells adhered to the glass substrate with marked morphological change within 3 hr of TPA treatment. Adherent cells became flat and amoeboid in shape, an...

background: the monoclonal antibody, c595, against breast cancer cell line was conjugated with cyclic anhydride gadolinium-diethylenetriaminepenta-acetic acid (gd-cdtpaa) to produce gd-dtpa-c595 and used as specific breast cancer cell line (mcf-7) contrast agents in magnetic resonance imaging (mri).  methods: after incubation of breast cancer cell line (mcf-7), with different contrast agents (g...