The maintenance of thyroid hormone (TH) homeostasis is dependent on the synthesis and secretion of TH regulated by TSH. This is achieved, in turn, by the negative feedback of TH on TSH secretion and synthesis, which requires the interaction with TH receptors (TRs). Derived by alternative splicing of two gene transcription products, three TRs (TR 1, TR 2 and TR 1) interact with TH while another,...

The chicken ovalbumin upstream promoter transcription factor (COUP-TF) is a member of the steroid/thyroid hormone receptor superfamily about which little is known of its functional role in the cell. However, it is able to repress hormonal induction of target genes by vitamin D3 receptor (VDR), thyroid hormone receptor (TR), and retinoic acid receptor (RAR). We have shown previously that COUP-TF...

The implied existence of two mechanisms for glucose uptake into heterotrophic plant cells was investigated using the fluorescent glucose derivative 2-NBDG (2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose), two membrane impermeable fluorescent markers (3000 mol. wt. dextran-Texas Red (d-TR) and Alexa-488), hexose carrier and endocytic inhibitors (phloridzin and wortmannin-A, respec...

BACKGROUND Stroke is one of the most disabling and costly impairments of adulthood in the United States. Stroke patients clearly benefit from intensive inpatient care, but due to the high cost, there is considerable interest in implementing interventions to reduce hospital lengths of stay. Early discharge rehabilitation programs require coordinated, well-organized home-based rehabilitation, yet...

The use of Hybrid Automatic Repeat reQuest (HARQ) for error correction has been given wide attention in the High Speed Downlink Packets Access (HSDPA) mode of the UMTS (3GPP TR 25.848 2001). This paper derives a theoretical analysis of the performance of Automatic Repeat reQuest (ARQ) and Type I Hybrid ARQ (HARQ I) over a block multipath Rayleigh fading channel. It is shown that the derived ana...

Background Tumor antigen-specific CD4 T cells generally orchestrate and regulate innate and adaptive immune cells to provide immune surveillance against malignancy. However, activation of antigen-specific CD4 T cells is restricted at local tumor sites where antigen-presenting cells are frequently dysfunctional, which can cause rapid exhaustion of anti-tumor immune responses. Herein, we characte...

<p>Ventricular Septal Defect (VSD) is a congenital heart disease that causes the connection between left and right ventricles called Gerbode defect. Manifestation of defect damage to opening tricuspid valve caused regurgitation valve. Delay in diagnosis intervention will affect pre-operative nutritional status malnutrition.</p><p>We reported boy aged 2 months, weighing 3100 gr...