BACKGROUND Numerous metabolic pathways have been implicated in diabetes-induced renal injury, yet few studies have utilized unbiased systems biology approaches for mapping the interconnectivity of diabetes-dysregulated proteins that are involved. We utilized a global, quantitative, differential proteomic approach to identify a novel retinoic acid hub in renal cortical protein networks dysregula...

Increasing numbers of children are suffering from hypoxia-related visual impairments such as retinopathy prematurity. This study aimed to investigate whether all trans retinoic acid reverses hypoxia related in retinal vasculature. Oxygen induced model was established mouse and the expression ciliary neurotrophic factor, vascular endothelial growth factor inducible 1 detected. We found that leve...

The metabolism of C3H]retinoic acid, both in uiuo and in vitro in a 10,000 X g supernatant preparation of small intestinal mucosa and liver of vitamin A-deficient hamsters, has been shown to be dependent upon pretreatment of the hamsters with retinoic acid. A proportional increase in both the in uiuo and the in vitro metabolism in the intestine and liv’er was found with inducing levels of retin...

Multidrug-resistant bacteria such as Staphylococcus aureus constitute a global health problem. Gram-positive S. secretes various toxins associated with its pathogenesis, and biofilm formation plays an important role in antibiotic tolerance virulence. Hence, we investigated if the metabolites of vitamin A 1 might diminish toxin production. Of three retinoic acids examined, 13- cis -retinoic acid...

The peroxisome proliferator-activated receptor (PPAR ) is a nuclear receptor family member that can form a heterodimeric complex with retinoid X receptor (RXR) and initiate transcription of target genes. In this study, we have examined the effects of the PPAR ligand ciglitazone and the RXR ligand SR11237 on growth and induction of retinoic acid receptor (RAR) expression in breast and lung cance...

Nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are thought to mediate most of the effects of retinoids on cell growth and differentiation. Despite expressing abundant levels of RARb mRNA, lung adenocarcinoma H1792 cells are resistant to the growthinhibitory effects of all-trans-retinoic acid, suggesting that they have a defect in retinoid signaling. To determine whether ...

We have measured the pharmacokinetics of three retinoids, all-trans retinoic acid, 13-cis retinoic acid, and fenretinide in rat blood and rat brain [especially white matter (WM) and gray matter (GM)] to help select retinoids for treating human malignant glioma. All-trans retinoic acid permeated well into the WM, giving peak concentration in WM of 25.7 microg/g, 6 to 7 times higher than the peak...

BACKGROUND The recent study described a better outcome in acute promyelocytic leukemia patients treated with all-trans retinoic acid and arsenic oxide compared to those treated with all-trans retinoic acid combined with conventional chemotherapy. The pivotal study indicated that favorable-risk acute promyelocytic leukemia patients can be cured without any cytotoxic chemotherapy. Even high-risk ...