Here we report that, unlike other ketones, 1-indanone and acetophenone derived enolates undergo Mannich-type addition reactions with N-tert-butanesulfinyl ketimines with excellent yields (up to 98%) and diastereoselectivity (>99/1). The resulting compounds represent a new type of biologically relevant β-aminoketone derivative bearing quaternary stereogenic carbon, which could be further convert...

House mice (genus Mus) harbor extensive allelic variation at two tandemly duplicated genes that encode the β-chain subunits of adult hemoglobin (Hb). Alternative haplotypes differ in the level of sequence divergence between the two β-globin gene duplicates: the Hbb(d) and Hbb(p) haplotypes harbor two structurally distinct β-globin genes, whereas the Hbb(s) haplotype harbors two β-globin duplica...

The cysteine protease cathepsin B is a potential drug target for reducing brain amyloid-β (Aβ) and improving memory in Alzheimer's disease (AD), as reduction of cathepsin B in transgenic mice expressing human wild-type amyloid-β protein precursor (AβPP) results in significantly decreased brain Aβ. Cathepsin B cleaves the wild-type β-secretase site sequence in AβPP to produce Aβ, and cathepsin B...

Background: Changes of body image following breast cancer is one of the factors affecting the quality of life of women with this disease. Objectives: Thus, the factors affecting the body image need to be identified to improve their quality of life. Therefore, this study aimed to investigate the factors affecting the body image in Iranian women diagnosed with breast cancer. Methods: In this cr...

Objective(s): Development of a nanobiosystem by using plant essential oils with green synthesized silver nanoparticles that present synergistic antibacterial activity for overcoming antibiotic resistance in pathogenic bacteria. Material and Methods: Essential oils (EOs) of Kelussia odoratissima and Teucrium polium extracted by hydrodistillation were analyzed by gas chromatography-mass spectrome...

In this paper we define and study intersection type assignment systems for first-order rewriting extended with application, λ-abstraction, and β-reduction (TRS+β). One of the main results presented is that, using a suitable notion of approximation of terms, any typeable term of a TRS+β that satisfies a general scheme for recursive definitions has an approximant of the same type. From this resul...

The first phase of insulin secretion is altered during the early stages diabetes and followed by progressive loss ability glucose to stimulate secretion. primary causes secretory defects are still unknown. Better understanding signaling pathways linked activation G-protein–coupled receptors their mutual interactions in β-cells remains crucial. This represents a prerequisite for any strategy dev...