We conducted a randomised single centre double blind cross over clinical trial to investigate the effects of a herbal tea containing Salacia reticulata (Kothala Himbutu tea) in patients with type II diabetes mellitus. Fifty-one patients with type II diabetes mellitus for longer than 6 months and with evidence of stable glycaemic control over the preceding 6 months (as assessed by HbA1C) partici...

We performed a network meta-analysis to compare the efficacy of 12 single-drug regimens (Glibenclamide, Glimepiride, Pioglitazone, Rosiglitazone, Repaglinide, Metformin, Sitaglitin, Exenatide, Liraglutide, Acarbose, Benfluorex, and Glipizide) in the treatment of type 2 diabetes mellitus (T2DM). Fifteen relevant randomized controlled trials (RCTs) were included; direct and indirect evidence from...

conclusions the results of the present study give some evidence that allows us to conclude that hardiness and coping strategies affect occupational life quality for both people suffering from type ii diabetes and healthy people. therefore, it is proposed that people strengthen their hardiness and coping strategies, in order to improve their occupational life quality. background due to the epide...

BACKGROUND Neonatal diabetes mellitus (NDM) due to KCNJ11 gene mutation presents with diabetes in the first 3 months of life and sometimes with neurological features like developmental delay, muscle weakness and epilepsy. METHODS A 5-week-old boy presented with diabetic ketoacidosis. Molecular genetic analysis of the patient revealed heterozygous missense mutation, L233F in the KCNJ11 gene, w...

Anxiolytic drugs may influence glycemic control in diabetic subjects, so the present study was conducted to investigate the effect of glimepiride, a commonly used oral hypoglycemic, diazepam, a commonly used anxiolytic, and their combination in STZ-induced diabetic rats. Diabetes was induced by streptozotpcin (50 mg/kg i.p.). Rats were divided into 5 groups namely: normal control, diabetic cont...

purpose: to determine the correlation between presumed risk factors and diabetic retinopathy (dr) in patients with type ii diabetes mellitus (dm). methods: this descriptive analytical study was performed on medical records of patients with type ii dm referred to a diabetes clinic in birjand valiasr hospital from september 2006 to september 2007. parameters included age, sex, duration of dm, typ...

abstract objective: the aim of current study was evaluation of group-based diabetes self-management education (group-based dsme) effectiveness in improving glycemic control among type 2 diabetic patients attending the yazd diabetes research center in 2014. materials and methods: the study design was quasi-experimental with control group.in this study, 62 diabetic patients were randomly allocate...

In this study, matrix-type transdermal patches of glibenclamide were developed using a combination hydrophilic and hydrophobic polymers for investigating the efficacy carriers. A cellulose derivative, HPMC E50, was used as matrix-forming polymer, Eudragit RS 100 polymer. The solvent casting technique employed to develop blend patch formulation chloroform methanol solvent. No drug–polymer intera...

The association between diabetes and cognitive impairment is controversial. This systematic review examines the relationship of Cognitive Impairment in people with diabetes mellitus. The incidence of “Cognitive Impairment” was higher in individuals with diabetes than in those without diabetes in nine of ten studies reporting this aggregate outcome. These findings showed an associated between ty...

Introduction: Endothelium and smooth muscle dysfunction are the most important complications of diabetes. In type 1 diabetic patients, absence of insulin leads to vasoconstriction and lower skin blood perfusion. Release of some mediators by endothelium which is induced by insulin causes vasodilation, but the exact mechanism of insulin vasodilatory effect is not detected properly. At present st...