generated in response to oxidative stress – play an important role in cell protection by performing functions like catalyzing the conjugation of a large variety of endogenous and exogenous compounds including ROS, carcinogenic compounds, and their metabolites. A previous study clearly demonstrated an abundance of GSTs in the male reproductive tract and showed that GSTs play important roles in t...

BACKGROUND Varicocele is associated with high levels of DNA damage in spermatozoa due to oxidative stress and elevated levels of sperm DNA fragmentation, which has been currently proposed to be an essential additional diagnostic test to be recommended for patients with clinical varicocele. The aim of this study was to evaluate the parameters of semen and the DNA fragmentation index (DFI) in pat...

OBJECTIVE This study sought to evaluate platelet volume indices (mean platelet volume [MPV], platelet distribution width [PDW], and platelet large cell ratio [P-LCR]) in varicocele patients, and compare it with platelet volume parameters in healthy controls. METHODS This cross-sectional study involved 2 groups: group 1 included 51 varicocele subjects and group 2 consisted of 50 healthy contro...

Neuronal apoptosis inhibitory protein (NAIP) and survivin might play an important role in testicular function. We investigated the effect of PDRN, an agonist of adenosine A2A receptor, on testicular NAIP and survivin expression in an experimental model of varicocele. After the creation of experimental varicocele (28 days), adolescent male Sprague-Dawley rats were randomized to one of the follow...

Varicoceles are present in 15% of the normal male population and in approximately 40% of men presenting with infertility. The preponderance of experimental data from clinical and animal models demonstrates a deleterious effect of varicoceles on spermatogenesis. Testicular temperature elevation and oxidative stress appear to play an important role in varicocele-induced testicular dysfunction, al...

INTRODUCTION The aim of study is determining the cost-effectiveness of detection analysis in the presence of exceptional patients who have mild semen disorders, and beware of unnecessary varicocele repairs; and to ascertain whether patients with clinical varicocele should undergo Y chromosome (Yq) microdeletion analysis as a routine procedure. MATERIAL AND METHODS Varicocele with reflux was d...

OBJECTIVES To study the impact of obesity, age and varicocele on sexual hormones of adult and elderly men. MATERIALS AND METHODS 875 men who were screened for prostate cancer were enrolled in this study. Data recorded comprised age, body mass index (BMI), serum levels of total testosterone (TT), free testosterone (FT), sex hormone-binding globulin (SHBG), luteinizing hormone (LH) and follicul...

There are some studies showing that varicoceles may cause injury to the testicle outside of the typical symptoms of infertility and pain. In a study of 835 men, 325 of which had a palpable varicocele demonstrated that those with a varicocele had significantly lower testosterone levels that those without, 416 versus 469 ng dl −1. 9 This effect of testosterone does not seem to be affected by grad...

The goal of surgical treatment of the varicocele is to occlude the refluxing venous drainage to the testis while maintaining normal testicular function. Many surgical techniques for treating varicoceles have been described. We aim to present an adolescent case with varicocele treated by simple laparoscopic ligation technique using intracorporeal knot-tying.

Objective(s): Increased levels of nitric oxide (NO) in the testicular veins of people suffering from varicocele have already been reported. However, the role of NO-synthase (NOS) isozymes and their inhibitors have not been extensively studied. We aimed to evaluate the inhibitory effects of aminoguanidine (AG), on sperm motility, vitality, and mitochondrial membrane potential (MMP) in varicoceli...