5. Isbister GK, Gray MR. White-tail spider bite: a prospective study of 130 definite bites by Lampona species. 'Mobile phone sign' in early vitamin B12 deficiency Sir, I greatly enjoyed the letter from Kozak and Schattner regarding 'Mobile Phone Sign' in early vitamin B12 deficiency. 1 I would, however, like to make one comment. I note that the patient reported in the letter was treated (succes...

OBJECTIVE There are few studies regarding vitamin B12 deficiency in developing countries. In Brazil, a late diagnosis of vitamin B12 deficiency progressing to severe neurological damage is common. Thus, the aim of the present study was to verify the frequency of vitamin B12 deficiency in two Brazilian populations (elderly and adult participants) and to compare different methods of vitamin B12 d...

Functional vitamin B2 levels were assessed in 600 children with autism aged between two and 30 years old. Every child was found to have functional deficiency. The deficiency appears stemmed from deficiencies Iodine, Selenium and/or Molybdenum as a previous report by this lab. is known essential co-factor the maintenance of activity B12, potentially would also mean that each deficient B12 – pred...

Vitamin B12 deficiency is common in elderly and vegetarians, but whether screening should be carried out only for these high risk groups or for the entire population, is controversial. Vitamin B12 assays performed on 422 patients in Biochemistry laboratory of tertiary care hospital over a period of 1 year were reviewed. Individuals were considered to be vitamin B-12 deficient if vitamin B-12 wa...

Introduction Neurotrophic keratitis is a rare degenerative corneal disease caused by an impairment of trigeminal corneal innervation, leading to a decrease or absence of corneal sensation. Here, we present a case of neurotrophic keratopathy caused by B12 deficiency in a 34 years old man who had a progressive decrease in visual acuity and corneal involvement since 3 months before being referred ...

The present report highlights an unusual presentation of vitamin B12 deficiency--recurrent seizures in a 26-year-old man. His symptoms responded to parenteral vitamin B12 therapy. The relevant literature is reviewed.

E NDOGENOUS VITAMIN B12 circulates bound to an alpha-i glycoprotein.”2 Added vitamin binds primarily to a globulin with beta mobility electrophoretically, which may serve mainly a temporary transport function.3’4 This beta globulin readily gives up its vitamin B12 to cells, while the alpha globulin seems to serve as a circulating storage depot.3’5’6 With the exception of some conditions involvi...

Vitamin B12, a co-factor in methyl-group transfer, is important in maintaining DNA (deoxycytidine) methylation. Using two independent assays we examined the effect of vitamin B12-deficiency (plasma vitamin B12<148 pmol/L) on DNA methylation in women of childbearing age. Coagulated blood clot DNA from vitamin B12-deficient women had significantly (p<0.001) lower percentage deoxycytidine methylat...