BACKGROUND Catharanthus roseus L (C. roseus) has been used to treat a wide assortment of diseases including diabetes. The objective of our study was to evaluate the antimicrobial and wound healing activity of the flower extract of Catharanthus in rats. METHODS Wound healing activity was determined in rats, after administration (100 mg kg-1 day-1) of the ethanol extract of C. roseus flower, us...

BACKGROUND The purpose of this manuscript was to determine whether the change in wound surface area over time could be described through nonlinear mathematics. METHODS We studied 3,588 serial wound tracings of 338 venous leg ulcers (VLUs) that had been followed during a controlled, prospective, randomized trial of two topical wound treatments. RESULTS A majority (72%) of VLUs exhibited surf...

BACKGROUND Hyperglycemia is known to adversely affect the outcome of ischemic insults, but its interaction with ischemia has not been investigated in wound repair yet. In this study, we develop a new animal model allowing to investigate the interaction between hyperglycemia and ischemia during the wound repair process. We focus on myofibroblast differentiation, a key element of wound repair. ...

We present a discrete stochastic model which represents many of the salient features of the biological process of wound healing. The model describes fronts of cells invading a wound. We have numerical results in one and two dimensions. In one dimension we can give analytic results for the front speed as a power series expansion in a parameter, p, that gives the relative size of proliferation an...

In a recent paper [1], once again fresh experimental wounds in murine skin were used to study the action of low-intensity (laser) light on the wound-healing process. And, as in many previous cases, irradiation of experimental wounds in rodent skin neither increased the wound closure nor affected the healing process by histological parameters. However, many publications over the decades have cla...

The wound-healing process has previously been modeled with exponential orwith linear curves. In the present study, we proposed a new model called the delayed exponential model, and compared all three models. Assessment of the models was based on healing data for two large groups of pressure ulcers in spinal-cord-injured (SCI) patients. The first group consisted of conventionally treated wounds ...

Wound healing represents a well orchestrated reparative response that is induced by injuries. Angiogenesis plays a central role in wound healing. In this work, we sought to develop the first mathematical model directed at addressing the role of tissue oxygen tension on cutaneous wound healing. Key components of the developed model include capillary tips, capillary sprouts, fibroblasts, inflamma...

Chronic wounds represent a major public health problem affecting 6.5 million people in the United States. Ischemia, primarily caused by peripheral artery diseases, represents a major complicating factor in cutaneous wound healing. In this work, we sought to develop a mathematical model of ischemic dermal wounds. The model consists of a coupled system of partial differential equations in the par...

Aqueous extract of the roots of Radix paeoniae (Paeonaceae) was screened for wound healing by excision, incision and dead space wound models on Wistar rats. The parameters studied were breaking strength in case of incision wounds, epithelialisation and wound contraction in case of excision wound and granulation tissue dry weight, breaking strength and hydroxyproline content in case of dead spac...