Translationally Controlled Tumor Protein (TCTP) is an almost ubiquitous protein found in eukaryotes, fundamental for the regulation of development and general growth. The multiple functions of TCTP have been inferred from its involvement in several cell pathways, but the specific function of TCTP is still not known in detail. On the other hand, TCTP seems to respond to a plethora of external si...

For any two binary vectors x = (x1, x2, . . . , xn) and y = (y1, y2, . . . , yn) in F2 , define the sets δ(x, y) = {i : xi 6= yi} and sup(x) = {i : xi 6= 0}. Denote the size of a set A with |A|. Then the Hamming distance between the binary vectors x and y is equal to d(x, y) = |δ(x, y)| and the Hamming weight of x is wt(x) = | sup(x)|. Instead of using the Hamming distance d(x, y) and norm wt(x...

An ultralightweight Fe–30Mn–13.2Al–1.6C–5Cr steel, which contains more than 13 wt% of Al and thereby reduces the density by 20%, is developed. The very brittle due to high content, fabricated optimizing hot rolling heat treatment conditions. Hot conducted after soaking at temperature range 1100–1200 °C for 2 h. steel hot‐rolled successfully 1100 °C, whereas specimens soaked 1150 1200 are interg...

Surface encrustation by minerals, which impedes cellular metabolism, is a potential hazard for microbes. The reduction of U(VI) to U(IV) by Shewanella oneidensis strain MR-1 leads to the precipitation of the mineral uraninite, as well as a non-crystalline U(IV) product. The wild-type (WT) strain can produce extracellular polymeric substances (EPS), prompting precipitation of U some distance fro...

C-terminal truncations of monomeric wild-type alpha-synuclein (henceforth WT-αS) have been shown to enhance the formation of amyloid aggregates both in vivo and in vitro and have been associated with accelerated progression of Parkinson's disease (PD). The correlation with PD may not solely be a result of faster aggregation, but also of which fibril polymorphs are preferentially formed when the...

One of the most intriguing questions in modern enzymology is whether enzyme dynamics evolved to enhance the catalyzed chemical transformation. In this study, dihydrofolate reductase, a small monomeric protein that catalyzes a single C-H-C transfer, is used as a model system to address this question. Experimental and computational studies have proposed a dynamic network that includes two residue...