The inclusion behavior of hydroxypropyl β-cyclodextrin and natural β-cyclodextrin was studied toward ketoprofen, in order to develop a new oral dosage form with enhanced dissolution rate and bioavailability, and to study the oral pharmacokinetics of ketoprofen in humans, following cyclodextrin complexation. Drug-cyclodextrin solid systems were prepared by kneading, co-evaporation, and freeze-dr...

Through the high affinity of the β-cyclodextrin (β-CD) cavity for adamantane moieties, novel polysaccharide-gold nanocluster supramolecular conjugates (HACD-AuNPs) were successfully constructed from gold nanoparticles (AuNPs) bearing adamantane moieties and cyclodextrin-grafted hyaluronic acid (HACD). Due to their porous structure, the supramolecular conjugates could serve as a versatile and bi...

The unusual self-assembly in chloroform of a novel cyclodextrin-based [2]pseudorotaxane, composed of heptakis-2,6-di-O-methyl-3-O-acetyl-β-cyclodextrin and a viologen-containing linear component, is reported.

The aim of this study was to evaluate hot-melt extrusion (HME) as a continuous process to form cyclodextrin (CD) inclusion complexes in order to increase the solubility and dissolution rate of itraconazole (ITZ), a class II model drug molecule of the Biopharmaceutics Classification System. Different CD derivatives were tested in a 1:1 (CD:ITZ) molar ratio to obtain CD ternary inclusion complexe...

A click chemistry approach based on the reaction between alkynylflavins and mono(6-azido-6-deoxy)-β-cyclodextrin has proven to be a useful tool for the synthesis of flavin-cyclodextrin conjugates studied as monooxygenase mimics in enantioselective sulfoxidations.

To improve the therapeutic potential of β-cyclodextrin (β-CD)-threaded acid-degradable polyrotaxanes (β-CD PRXs) in cholesterol-related metabolic disorders, we investigated effect carboxylation β-CD PRXs on intracellular uptake. In this study, established a synthetic method for modification carboxylalkyl carbamates without degradation and synthesized three series carboxyalkyl carbamate group-mo...

Abstract The construction material from anhydrite-II phosphogypsum is dense in structure and has good water resistance. But its disadvantages are low hydration activity long setting time. In this work, modified by adding a composite activator, which made of sulfuric acid steel slag, β-hemihydrate gypsum calcium aluminate cement. With this, the rate clearly increased time shortened. performance ...

Single step pretreatment-saccharification of corn stover was investigated in aqueous p-toluenesulfonic and sulfuric acid media. Dilute aqueous solution of p-toluenesulfonic acid was a better catalyst than aqueous sulfuric acid of the same H(+) ion concentration for single step pretreatment-saccharification of corn stover at moderate temperatures and pressures. For example, 100mg corn stover hea...

in the present study, sulfuric acid was used for artemia cysts decapsulation. cysts of artemia franciscana were hatched out in regular manner or following hypochlorite or acid decapsulation. two acid concentrations (1 and 5%), three acid immersion times (10, 30 and 50 min) were used and hatching rates were recorded after 15, 18 and 24 h incubation. hatching rates increased but hatching time dec...