This study reports four cases of transmission of the rare hepatitis C virus genotype 4 which occurred in a hemodialysis unit and originated from a single source of infection. Phylogenetic analyses performed with the NS5b domain showed that all four patients with secondary infections were infected with virus strains very similar to that of the index patient. Cross infections probably resulted fr...

2'-Deoxy-2'-fluorocytidine (FdC) is a potent inhibitor of the hepatitis C virus RNA replicon in culture, and FdC-5'-triphosphate is an effective inhibitor of the NS5B polymerase. Dynamic profiling of cell growth in an antiviral assay showed that FdC caused cytostasis due to an S-phase arrest. These observations demonstrate that FdC treatment is affecting both a viral target and a cellular target.

یکی از خلاقانه­ترین نمونه­های بازخوانی اسطوره در ادبیات آلمانی­زبان رمان جهان آخر اثر نویسندۀ اتریشی کریستف رانس­مایر است که آن اسناد تاریخی دربارۀ زندگی شاعر ملی رم باستان اوید و بن­مایه­های کتاب دگردیسی­های او قالب پیرنگ مدرنی بازنمایی شده­اند. روایت­های کهن را با تجربه­های زیستی تفکر انتقادی معاصر درهم آمیخته روایت نشانه­های انحطاط همه­جانبه­ای مشاهده کرده به باور وی ویژگی­های تمدن امروز بشر...

3'-Deoxy-4'-azaribonucleosides (15a-d) were synthesized starting from the commercially available (4R)-trans-4-hydroxy-l-proline 7. From biological evaluations, 15b and 15d emerged as potent inhibitors of HCV replication on a replicon assay. These findings demonstrate that synthesized pyrrolidine nucleosides represent a new template for antiviral or other biological studies and could be consider...