Hyaluronan (HA) is a major component of the extracellular matrix (ECM), and influences tumor invasion and metastasis. In a previous study, the present authors reported for the first time that 4-methylumbelliferone (MU) inhibited HA synthesis and suppressed tumor growth. However, the localization of HA and the changes in ECM morphology caused by MU in pancreatic cancer remain to be examined in d...

Bayesian evolutionary analysis provide a statistically sound and flexible framework for estimation of evolutionary parameters. In this method, posterior estimates of evolutionary rate (μ) are derived by combining evolutionary information in the data with researcher’s prior knowledge about the true value of μ. Nucleotide sequence samples of fast evolving pathogens that are taken at d...

OBJECTIVE In an effort to understand better the federal electronic health record (EHR) incentive programme's challenges, this study compared hospitals that did and did not receive meaningful use (MU) payments in the programme's first year based on the challenges they anticipated a year before. MATERIALS AND METHODS This cross-sectional study used 2010 American Hospital Association survey data...

The mu rhythm is a field oscillation in the ∼10Hz range over the sensorimotor cortex. For decades, the suppression of mu (event-related desynchronization) has been used to index movement planning, execution, and imagery. Recent work reports that non-motor processes, such as spatial attention and movement observation, also desynchronize mu, raising the possibility that the mu rhythm is associate...

The increasingly attractive stereotactic body radiotherapy (SBRT) treatment for stage I lung cancer is concomitant with a large amount of monitor units (MU), leading to excessive out-of-field dose and prolonged beam-on time. The study aims to reduce the MU number and shorten the beam-on time by optimizing the planning parameters. Clinically acceptable treatment plans from fourteen patients suff...

Cross-linking of surface Ig receptors with anti IgM (anti-mu heavy chain, anti-mu), but not anti-IgD (anti-delta heavy chain, anti-delta), Abs leads to growth arrest and apoptosis in several extensively characterized B cell lymphomas. By poorly understood mechanisms, both Igs transiently stimulate c-Myc protein expression. However, ultimately, only anti-mu causes a severe loss in c-Myc and a la...

كچ ي هد فده و هقباس : شبات ،هتشذگ ههد لوط رد ناديم زا يشان يريگ نتنآ زا لصاح يسيطانغمورتكلا ياه هدـنريگ ياه / ت هدنتسرف تسا هتفاي شيازفا هارمه نفل . هعلاطم نيا In vivo جاوما رثا يسررب روظنم هب 950 نـفلت متسيس زترهاگم هارمه GSM ينلاوط تيوقت رب تدم ) LTP ( هيحان Dentate gyrus تفرگ تروص . شور و داوم اه : 32 ر أ داژن زا ركذم يهاگشيامزآ گرزب شوم س Wistar دودح ينس اب 3 نزو و هام 15 ± 220 ـ گ ،مر...

INTRODUCTION A contributing factor to the loss of muscle mass and strength during aging is the reduction in the number of functioning motor units (MU). It has been shown that lifelong physically active older rats have greater numbers of MU compared with age-matched sedentary controls, suggesting that chronic exercise may preserve MU function with advancing age. This has not previously been exam...

New mini-Mu transposons with plasmid replicons were constructed with additional features for in vivo DNA cloning and lac gene fusing in Escherichia coli. These mini-Mu replicons can be used to clone DNA by growing them with a complementing Mu bacteriophage and by using the resulting lysate to transduce Mu-lysogenic cells. These mini-Mu phage have selectable genes for resistance to kanamycin, ch...