Abstract The role of active antitumor immunity in hormone receptor–positive (HR+) breast cancer has been historically underlooked. aim this study was to determine the contribution immune system antiprogestin-induced tumor growth inhibition using a hormone-dependent model. BALB/c-GFP+ bone marrow (BM) cells were transplanted into immunodeficient NSG mice generate an immunocompetent NSG/BM-GFP+ (...

CCR5 disruption by zinc finger nucleases (ZFNs) is a promising method for HIV-1 gene therapy. However, successful clinical translation of this strategy necessitates the development of a safe and effective method for delivery into relevant cells. We used non-integrating lentivirus (NILV) for transient expression of ZFNs and pseudotyped the virus with HIV-envelope for targeted delivery to CD4(+) ...

Strongyloides stercoralis hyperinfection causes high mortality rates in humans, and, while hyperinfection can be induced by immunosuppressive glucocorticoids, the pathogenesis remains unknown. Since immunocompetent mice are resistant to infection with S. stercoralis, we hypothesized that NSG mice, which have a reduced innate immune response and lack adaptive immunity, would be susceptible to th...

New therapies are required for melanoma. Here, we report that multiple cardiac glycosides, including digitoxin and digoxin, are significantly more toxic to human melanoma cells than normal human cells. This reflects on-target inhibition of the ATP1A1 Na(+)/K(+) pump, which is highly expressed by melanoma. MEK inhibitor and/or BRAF inhibitor additively or synergistically combined with digitoxin ...

In a Network Security Game (NSG), security agencies must allocate limited resources to protect targets embedded in a network, such as important buildings in a city road network. A recent line of work relaxed the perfect-rationality assumption of human adversary and showed significant advantages of incorporating the bounded rationality adversary models in non-networked security domains. Given th...

Background TGFbeta production by solid tumors and their microenvironment is a major mechanism used to avoid immunosurveillance. Blockade of has been shown promote an anti-tumor response; however, systemic blockade also associated with toxicity. We hypothesized that T cell-targeted TGFbR2 bispecific antibody could selectively block the suppressive activity on cells enhance while avoiding toxicit...

Abstract Non-small cell lung cancer (NSCLC) is the leading cause of malignancy-related deaths worldwide. We wished to overcome a current major limitation PDX modeling, by providing autologous human T cells suitable for immunotherapy responses, but notably, without graft versus host disease (GVHD). have developed PDXs from NSCLC implanting surgically resected patient tumors subcutaneously in NOD...