Background: Ferula species have shown wide range of pharmacological properties but there is no study on oral safety profile of Ferula persica due to standard toxicology guidelines. Objective: This study aimed to evaluate the acute and subchronic oral toxicity of the alcoholic extract of the aerial parts of Ferula persica to provide its safe dose for long term oral administrations as a possible...

The effect of methanolic extract of Hymenocardia acida leaves on diabetes and associated lipidemia were investigated on experimentally-induced diabetic rats. The extract did not demonstrate any acutely toxic effect in rats within the dose range (250 mg/kg - 2000 mg/kg) employed in the study; hence it was well tolerated by the rats. In all experiments, the anti-diabetic effects were dose-depende...

Sir, Studies in vitro and in animals have shown that killing of bacteria by -lactams is time dependent and maximal at relatively low concentrations, indicating optimal administration by continuous infusion. Continuous infusion of ceftazidime was recently reported to be well tolerated by children with cystic fibrosis. On the other hand, the bactericidal activity of aminoglycosides is concentrati...

This study was carried in order to determine short-term (acute) and long-term(subchronic) effects of Melastomastrum capitatum leaf methanol extract in the management and treatment of certain diseases in traditional and complementary medicines  by many villages in Mambila Nigeria. Acute and subchronic toxicities were carried out in  accordance with the Organization for Economic Cooperation and D...

Abstract Corn was grown under greenhouse conditions in the presence of uncleaned versus cleaned municipal sewage sludge to assess effectiveness a chemical leaching process that uses an inorganic acid and strong oxidants clean biosolids (i.e., remove metals without reducing their agronomic potential). Specifically, our study analyzed physicochemical from Montreal (MSL) wastewater treatment plant...