Insulin resistance has been documented in type 1 diabetes and may contribute to the high risk for cardiovascular disease in this population and progression of nephropathy. We investigated associations of renal parameters, including urinary albumin excretion rate (UAE), serum creatinine and creatinine clearance, with surrogate measure of insulin sensitivity calculated using a formula derived fro...

BACKGROUND The synthesis of albumin after oral ingestion of nutrients provides a means of storing amino acids, which can be made available during periods of fasting. OBJECTIVE This study was undertaken to see whether the response of albumin synthesis to the oral intake of nutrients is compromised in elderly subjects. DESIGN Albumin synthesis was determined from the incorporation of 43 mg l-...

ETHNOPHARMACOLOGICAL RELEVANCE Stellera chamaejasme L. (Thymelaeaceae) was a toxic perennial herb and widely used as pesticide and dermatological agents in China. Chamaechromone was a major component in the dried roots of Stellera chamaejasme with anti-HBV and insecticidal activity. Analysis of metabolic profile in vivo and in vitro plays a pivotal role to unravel how TCM works. And the metabol...

In order to assess possible synergistic antinociceptive interactions, the analgesic effects of intra-peritoneal tramadol and morphine administered either separately or in combination were determined using tail-flick latency test following exposure to radiant heat in rats. Groups of eight male Sprague-Dawley rats received either tramadol (3.90, 7.00, 12.50, and 22.20 mg kg-1) and morp...

Ascorbic acid (vitamin C) supplementation has been documented as a useful tool to improve the performance of laying birds reared under harsh environmental conditions. However, there is limited information on the use of ascorbic acid as a means of ameliorating the stressful conditions imposed by feed restriction. To this effect a 3 × 2 factorial experiment was carried out to evaluate the effect ...

Objective(s):Rapamycin is an immunosuppressant compound with a broad spectrum of pharmaco-logical activities. In recent years, it has been used successfully to decrease ischemia-reperfusion injury in several organ systems. The purpose of the present study was to examine the effect of rapamycin on testicular ischemia-reperfusion injury. Materials and Methods: Seventy-two adult male Wistar rats w...

A study was conducted to determine the effects of dietary vitamin C on growth performance, feed utilization and carcass biochemical composition of Barbus sharpeyi fingerling. Five diets containing (0, 500, 1000, 1500 and 2000 mg kg-1) of ascorbic acid were fed to benni fingerlings (6.96±0.3 g) in triplicate tanks and twice daily for a period of 56 days. The weight gain significantly increase...

Neuronal cultures in vitro readily oxidized both D-[(14)C]glucose and l-[(14)C]lactate to (14)CO(2), whereas astroglial cultures oxidized both substrates sparingly and metabolized glucose predominantly to lactate and released it into the medium. [(14)C]Glucose oxidation to (14)CO(2) varied inversely with unlabeled lactate concentration in the medium, particularly in neurons, and increased progr...