background: aminoglycoside antibiotics are widely used in medical centers, particularly to treat infections. the resistance developed against these agents is a huge concern in health care. a number of researchers have reported that hospital and municipal wastewaters are among the most important dissemination sources of these agent into the environment. some, however, do not agree with this opin...

BACKGROUND To evaluate ocular biometric parameters in different subtypes of acute angle closure and compared to fellow eyes of AAC and PACS eyes. METHODS This is a retrospective chart review study. A total of 167 eyes (96 patients) consisting of 71 AAC eyes, 71 fellow eyes of AAC, and 25 PACS eyes were recruited. All patients underwent ocular examination and biometry. The mechanism of AAC was...

1 pharmacokinetic model 2 3 4 5 Karen E. Bowker*, Alan R Noel and Alasdair P MacGowan 6 7 Bristol Centre for Antimicrobial Research and Evaluation 8 Department of Microbiology 9 Southmead Hospital 10 Westbury-on-Trym 11 Bristol 12 BS10 5NB 13 14 15 *Corresponding author 16 Tel 01179 9595654 17 Fax 0117 9593217 18 Email [email protected] 19 20 Running title: minocycline pharmacodynamics 21...

A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction 1 factor SAMHD1 2 3 Laurence H. Arnold, Simone Kunzelmann, Martin R. Webb and Ian A. Taylor 4 Division of Molecular Structure, Division of Physical Biochemistry, MRC National 5 Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK. 6 7 Running Title: Triphosphohydrolase activity of SAMH...

OBJECTIVES To investigate the presence of antibiotic resistance genes (ARGs), related to commonly used β-lactams and quinolones, in Escherichia coli present in hospital wastewater in central India. METHODS Cefotaxime- and ciprofloxacin-resistant E. coli isolates from hospital-associated wastewater samples were collected from two tertiary care hospitals in the Ujjain district of India during 2...

Objective. Plasmid-mediated quinolone resistance (PMQR) plays an important role in the development of clinical resistance to quinolone. The aim of this study was to investigate PMQR determinants among extended-spectrum β-lactamases- (ESBL-) producing Klebsiella pneumoniae recovered from patients with nosocomial urinary tract infection (UTI). Methods. A total of 247 ESBL-producing K. pneumoniae ...

AIMS This study aimed to evaluate the relationship between aortic arch calcification (AAC) detectable on chest X-ray films and plasma diacron-reactive oxygen metabolites (d-ROMs) in patients with type 2 diabetes but without cardiovascular disease. METHODS Forty-nine patients with type 2 diabetes but without cardiovascular disease were evaluated with chest X-ray examinations and divided into t...