The goal of this study was to determine whether the severity of disruption of the blood-brain barrier during acute hypertension is similar in open and closed cranial window preparations. Intravital fluorescent microscopy and fluorescein-labeled albumin were used to evaluate disruption of the blood-brain barrier under control conditions and during acute arterial hypertension in 10 rats equipped ...

• No family history of hypertension in a thin child • Age younger than 10 years and prepubertal stage • Acute rise in blood pressure previously normal • Severe hypertension (SBP/DBP ≥ 99th percentile plus 5 mmHg) • Mild hypertension (SBP/DBP ≥ 95th percentile plus 5 mmHg) in systemic disease • Nocturnal hypertension, reduced nocturnal dipping or diastolic hypertension at 24-hour BP monitoring •...

Spontaneously hypertensive rats are less susceptible than normotensive rats to disruption of the blood-brain barrier during acute hypertension. The purpose of this study was to examine mechanisms that protect the blood-brain barrier from disruption in chronically hypertensive rats during acute hypertension. Normotensive Wistar-Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (S...

Mild (140 to 159/90 to 99 mmHg) or moderate (160 to 179/100 to 109 mmHg) chronic arterial hypertension does not appear to cause headache. Whether moderate hypertension predisposes patients to headache at all remains controversial, but there is little evidence that it does. Ambulatory blood pressure monitoring in patients with mild and moderate hypertension has shown no convincing relationship b...

Pheochromocytoma is a catecholamine-producing adrenal tumor, being a rare cause of hypertension in pregnancy. It's prevalence in hypertensive patients is 0.2%, and 0.002% of pregnancies. We follow hypertensive pregnant 24 year old on her third pregnancy, admitted to 33 weeks with hypertensive emergency cesarean section indicated by fetal distress evolving with acute pulmonary edema in the post-...

Acute hypertension in Sprague-Dawley rats (SD) provokes a decrease in renal proximal tubule (PT) salt and fluid reabsorption, redistribution of apical Na/H exchanger isoform 3 (NHE3) and Na-P(i) cotransporter type 2 (NaPi2) out of the brush border into higher density membranes, and inhibition of renal cortical Na-K-ATPase (NKA) activity (41). The aims of this study were to determine 1) whether ...

Globally, it is estimated that > 140 million people live at a high altitude (HA), defined as > 2,500 m (8,200 ft), and that countless others sojourn to the mountains for work, travel, and sport. The distribution of exposure to HA is worldwide, including 35 million in the Andes and > 80 million in Asia, including China and central Asia. HA stress primarily is due to the hypoxia of low atmospheri...

a retrospective study was conducted on 50 pregnancies in 41 kidney transplant recipients. 37 pregnancies were successful (74%), while in 13 cases the pregnancy was lost (7 abortions,s intra-uterine fetal deaths and one therapeutic termination). the pregnancy course was uneventful in 38 cases (76%) but in 12 there were complications, such as hypertension or slight rise in serum creatinine. pregn...

Hypertension is a common problem affecting 60-70 million people in the United States [1]. Two thirds of patients are unaware that they have hypertension [2]. While it is well known that poorly controlled hypertension is a major risk factor for cardiovascular and cerebrovascular mortality, acute severe elevation in the blood pressure can also cause acute end organ damage. Approximately 1-2% of a...