Objective: To determine the diagnostic accuracy of non-invasive hepatic ultrasound score for diagnosis non-alcoholic fatty liver disease (NAFLD) by keeping computed tomography. (CT) as gold standard.
 Study Design: Cross-sectional study.
 Place and Duration Study: Armed Forces Institute Radiology Imaging Rawalpindi from Dec 2017 to May 2018.
 Methodology: All patients any ethnici...

The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major impact on the severity of the clinicopathologic outcome of non-alcoholic fatty liver disease. A short comprehensive review is provided on current knowledge of the pathophysiological interplay among major circulating effectors/mediators of fatty liver, such as circula...

are also associated with a greater risk of NAFLD and NASH at any given body mass index, and preliminary evidence suggests greater liver fat content in certain ethnicities that are also known to be at increased risk of type 2 diabetes. Preliminary evidence suggests a genetic predisposition to hepatic accumulation of fat in some people through the PNP3A gene. Such people may not necessarily displ...

Nonalcoholic fatty liver disease (NAFLD) is present in up to one third of the general population and in the majority of patients with metabolic risk factors such as obesity and diabetes. Insulin resistance is a key pathogenic factor resulting in hepatic fat accumulation. Recent evidence demonstrates NAFLD in turn, exacerbates hepatic insulin resistance and often precedes glucose intolerance. On...

Non-alcoholic fatty liver disease (NAFLD) is a heterogeneous disease that may range from simple steatosis (non-alcoholic fatty liver, NAFL) to non-alcoholic steatohepatitis (NASH) which can progress to advanced fibrosis and cirrhosis and is currently one of the most common chronic liver diseases in Korea and worldwide. Furthermore, in parallel with the increasing prevalence of obesity, type 2 d...

OBJECTIVES The purpose of this review to collate current leading scientific advances of molecular mechanisms in alcoholic liver diseases and to propose a working "hypothesis of seven balances" in relation to peroxisome proliferator activated receptor alpha (PPARalpha), which has important roles in fatty acid oxidation, oxidative stress, inflammatory responses, and possibly liver fibrosis. MET...

results the relative expression of mtdna copy number was 3.7 fold higher in nafld patients than healthy controls (p < 0.0001). the results remained significant after adjustment for age, bmi, and gender (p = 0.02). in addition, the mtdna copy number was 4.3 (p < 0.0001) and 3.2-fold (p < 0.0001) higher in nonalcoholic fatty liver (nafl) and non-alcoholic steatohepatitis (nash) patients than heal...

background: we tested whether hepatic haemodynamics assessed by doppler ultrasonography can be a predictor of response to therapy in patients with non‑alcoholic fatty liver disease (nafld) to prevent further unnecessary diagnostic tests and interventions. methods: forty eight consecutive patients affected by nafld, who refered to some clinics in tabriz, iran between 2009 and 2011 were included ...

conclusions considering the significant decrease in the liver enzymes, triglycerides and cholesterol after using berberis vulgaris extract, further studies with larger sample sizes will identify the accurate dose as well as duration of consumption for this extract, to recommend in the treatment of patients with nafld. results in the case group, the mean serum levels of alanine transaminase (alt...