introduction: constipation is one of the most common complaints of individuals, which may present with complication like hemorrhoid and fissure. hirschsprung is a disease presenting with chronic constipation and its diagnosis may be delayed until adulthood. it is diagnosed by biopsies from anorectal transitional zone. this study aimed to evaluate the association between hirschsprung and anorect...

PURPOSE The constant presence of a narrow subcutaneous tract extending caudad to chronic fissures-in-ano is reported. The efficacy of surgically unroofing this tract (subcutaneous fissurotomy) without sphincterotomy was evaluated. METHODS By using a narrow-gauge, hooked probe, a constant, midline subcutaneous tract was identified extending from the caudad aspect of chronic anal fissures. Thes...

Introduction: Anal fissure is a common ailment of young age group, affecting males and females alike. Traditionally surgery has been the 1st line of treatment but recently the topical agents such as Glyceryl Trinitrate and Diltiazem are replacing the surgical treatment as preferred modality. Objective: The present study was conducted to compare the topical GTN and DTZ in terms of effectiveness,...

The aim of this study was to develop a preparation of a hydroalcoholic extract of Quercus infectoria in order to study the physicochemical parameters, and to identify and quantitatively determine the amount of Polyphenols and Tannin in the galls and in the extract. Preparation of an extract rich in Tannin from the galls of Quercus infectoria, as an astringent, can make incorporation into recta...

OBJECTIVES To determine the efficacy and safety of 'healer' cream as monotherapy in the treatment of acute and chronic anal fissure. STUDY DESIGN A prospective, randomized, single blinded, comparative trial. METHODS Sixty patients suffering from anal fissure were included in the study. Patients were randomly divided into three groups: group A: treated with 'healer' local cream application 3...

OBJECTIVES To compare the potential impact of rectal (RMB), vaginal (VMB) and bi-compartment (RVMB) (applied vaginally and protective during vaginal and anal intercourse) microbicides to prevent HIV in various heterosexual populations. To understand when a RMB is as useful than a VMB for women practicing anal intercourse (AI). METHODS Mathematical model was used to assess the population-level...