BackgroundLoop diuretics are the main treatment for patients with acute heart failure, but associated neurohormonal stimulation and worsening renal function do not improve long-term outcomes. Antagonists to arginine vasopressin may provide an alternative strategy avoid these effects. The AVANTI study will investigate efficacy safety of pecavaptan, a novel, balanced dual-acting V1a/V2 antagonist...

Previous studies reported that mild inflammation promotes retinal ganglion cell (RGC) survival and axonal regeneration after optic nerve (ON) injury with involvement of infiltrating macrophages neutrophils. Here we aimed to evaluate the regulation main inflammatory chemokine pathway CXCL5/CXCR2 in inflammation-mediated RGC mice ON injury. The expressions cellular locations CXCL5 CXCR2 were conf...

This study was performed to determine the action mode of oxytocin antagonist. In Study 1, the duration of in vivo action of oxytocin antagonist I (AI) was examined. After infusing AI, oxytocin was given and repeated every hour for 5 hr. Uterine activities were monitored with a polygraph. Study 2 determined the effect of AI on uterine oxytocin receptor number (Rn) and binding affinity (Kd). AI t...

Abstract Study question Could exogenous progestin replace the use of an antagonist GnRH (GNRH-antagonist) without any effects on embryo morphokinetics and implantation rate in freeze-all cycles? Summary answer Exogenous leads to slower development increased cyclés cancellation rate, with when compared cycles using GnRH-antagonist. What is known already Improvements cryopreservation techniques a...

The involvement of inhibitory transmitters for Ptychodiscus brevis toxin (PbTx)-induced depression of spinal synaptic transmission in neonatal rats was investigated. Stimulation of a dorsal root evoked monosynaptic reflex (MSR) and polysynaptic reflex (PSR) potentials in the segmental ventral root. The PbTx depressed the reflexes in a concentration-dependent manner and this depression was block...

Background Our objective was to evaluate the effectiveness of clomiphene citrate (CC) vs. letrozole (L) plus human menopausal gonadotropin (hMG) in gonadotropin releasing hormone (GnRH) antagonist protocol in poor prognosis women with previous failed ovarian stimulation undergoing intracytoplasmic sperm injection (ICSI). MaterialsAndMethods This retrospective cohort study included cycles with C...

The authors conducted an experimental study in male human volunteers to examine the effects of a neurokinin type 1 receptor (NK1R) antagonist on aldosterone secretion. findings show presence Substance P (SP)-positive nerve fibres adrenal cortex vicinity aldosterone-producing cells and with role mineralocorticoid synthesis.