The relationship of erythromycin biosynthesis to growth appears to vary with the fermentation medium in which the microorganism is grown. In a medium containing a complex nitrogen source, antibiotic production occurred only when growth was halted, whereas in a glycine-containing synthetic medium the two parameters increased at nearly the same time. An autostimulation of antibiotic production th...

Human-associated microbial communities play important roles in health and disease. Antibiotic administration is arguably one of the most important modifiable determinants of the composition of the human microbiota. However, quantitatively modeling antibiotic use to account for its impact on microbial community dynamics presents a challenge. We used antibiotic therapy of chronic lung infection i...

INTRODUCTION Most developing countries are adopting antibiotic policies to contain the acute problem of drug resistance; however, several obstacles prevent their fulfillment. This study was undertaken to prospectively determine the compliance with the antibiotic policy in the intensive care unit (ICU) of a tertiary care hospital and possible reasons for non-compliance. METHODOLOGY Compliance ...

BACKGROUND Inappropriate antibiotic use significantly contributes to antibiotic-resistance, resulting in reduced antibiotic efficacy and increasing physical burden and cost of disease. The goal of this study was to explore antibiotic usage patterns in South Korea using 2007-2014 health insurance claims data. METHODS We used the Health Insurance Review & Assessment Service data, which represen...

OBJECTIVES To investigate changes in ulcer healing time and antibiotic treatment in Sweden following the introduction of the Registry of Ulcer Treatment (RUT), a national quality registry, in 2009. DESIGN A statistical analysis of RUT data concerning the healing time and antibiotic treatment for patients with hard-to-heal ulcers in Sweden between 2009 and 2012. SETTING RUT is a national web...

BACKGROUND Decreases in antibiotic use were widely reported in the 1990s. This study was undertaken to determine trends in the use of antibiotics from fiscal year (FY) 1995 (April 1995 to March 1996) to FY 2001 in a complete population of Manitoba children. METHODS Using Manitoba's health care databases, we determined annual population-based rates of antibiotic prescription among children by ...

OBJECTIVES To determine how important governmental, social, and economic factors are in driving antibiotic resistance compared to the factors usually considered the main driving factors-antibiotic usage and levels of economic development. DESIGN A retrospective multivariate analysis of the variation of antibiotic resistance in Europe in terms of human antibiotic usage, private health care exp...

introduction: the purpose of this study was to compare the setting time and post-setting solubility, flow, film thickness and dimensional changes of ah26 root canal sealer with ah26-antibiotic combination. materials and methods: this study was performed according to british standard bs 6876 (2001) which tests the physicochemical properties of endodontic sealers. three samples of each of tested ...