BACKGROUND The high frequency of cutaneous mycosis justify the need to evaluate the possible contribution of in vitro profile of susceptibility to antifungal agents. OBJECTIVE To evaluate whether there is variability in in vitro susceptibility by filamentous fungi, previously isolated from cutaneous mycosis, to fluconazole, ketoconazole, itraconazole and terbinafine. METHODS Fungi were isol...

keywords: Candiduria, Non albicans Candida, Antifungal susceptibility testing ABSTRACT Objective: The incidence of Candida has been on rise worldwide. Urinary tract infections [UTIs] as a result of Candida species are becoming, common in hospitalised patients. Clinicians face dilemma in differentiating colonization from true candiduria. The species identification of Candida is important, as non...

OBJECTIVES The aim of this study was to determine the genetic variability of clinical isolates morphologically identified as Fusarium oxysporum and to assess if there are differences in antifungal susceptibility among the possible genetic clades obtained. METHODS Twenty-eight isolates were molecularly characterized by sequence analysis of the elongation factor 1alpha gene. The antifungal susc...

Despite availability of many antifungal agents, antifungal clinical resistance occurs, perhaps as a consequence of an infecting organism found to be resistant in vitro to one or more antifungals tested. From what derives the important current role of the in vitro antifungal susceptibility testing (AFST), that is to determine which agents are like to be scarcely effective for a given infection. ...

There has been a dramatic increase in infections caused by candida worldwide. They are most commonly treated by fluconazole, which has led to emergence of fluconazole resistant candida. Also C krusei show innate resistance and C. glabrata & C. tropicalis show reduced susceptibility to fluconazole. Hence we undertook this study to speciate andto determine antifungal susceptibility pattern of

We measured antifungal activity against 128 cryptococcal isolates (86 of C. neoformans and 42 of C. gattii) to determine if differences in serotype susceptibility exist. Contrary to previous results, we found no serotype susceptibility differences. Isavuconazole, posaconazole, and voriconazole demonstrated excellent potency against each isolate and serotype, including isolates with reduced fluc...

Application of pharmacodynamic principles to antifungal drugs has provided an understanding of the relationship between drug dosing and treatment outcomes similar to that observed in antibacterial pharmacodynamics. Initial observations with triazole pharmacodynamics have correlated with clinical trial results and proved useful for validation of in vitro susceptibility breakpoints. Pharmacodynam...

BACKGROUND & OBJECTIVES During recent decades, there has been a change in the epidemiology of Candida infections, characterized by a progressive shift from a predominance of Candida albicans to non-albicans Candida species. This study was undertaken to analyze the change in the epidemiology of candidaemia and antifungal use at tertiary care hospital in New Delhi, India, over a period of 10 year...