This study was aimed at determining the analgesic effects of vigabatrin (VGB, a newer antiepileptic drug) in the acute thermal pain model (hot-plate test) in mice. Linear regression analysis was used to evaluate a dose-response relationship between logarithms of VGB doses and their resultant maximum possible antinociceptive effects (MPAE) in the hot-plate test in mice. From the linear equation ...

AG-4 has been characterized as a nicotinic agonist by binding (Ki = 26 ± 1.4 μM) and in vitro functional assays. The antinociceptive effect of AG-4 was examined in mice and rats, using the hot plate, abdominal constriction, and paw-pressure tests. In both species, AG-4 (25–150 μg per mouse icv; 100–150 μg per rat icv) produced significant antinociception which was prevented by mecamylamine (2 m...

The influence of naloxone (NAL), a competitive antagonist of mu, kappa, delta and sigma receptors; D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH(2) (CTOP), selective antagonist of mu-opioid receptors; nor-binaltorphimine (NOR-BNI), a potent and higly selective kappa opioid receptor antagonist; naltrindole (NTI), a delta-opioid receptor antagonist and naltriben (NTB), a highly selective delta(2)-opioid...

Pontospinal noradrenergic neurons are thought to form part of a descending endogenous analgesic system that exerts inhibitory influences on spinal nociception. Using optogenetic targeting, we tested the hypothesis that excitation of the locus ceruleus (LC) is antinociceptive. We transduced rat LC neurons by direct injection of a lentiviral vector expressing channelrhodopsin2 under the control o...

We investigated the antinociceptive and nerve excitability effects of the N-salicyloyltryptamine (NST) NST-treated mice exhibited a significant decrease in the number of writhes when 100 and 200 mg/kg (i.p.) were administered (i.p.). This effect was not antagonized by naloxone (1.5 mg/kg, i.p.). NST inhibited the licking response of the injected paw when 100 and 200 mg/kg were administered (i.p...

croton guatemalensis lotsy (cgl), known as “copalchi” in chiapas, mexico, is used for the treatment of fever, abdominal pain and malaria and also as a remedy for chills and for treating rheumatism. the aim of this study was to evaluate whether aqueous extracts from the bark of this plant possesses indeed antinociceptive properties by using two different animal models of nociception, the acetic ...

Methanolic extract of whole plant of Amaranthus viridis L (MEAV), was screened for antinociceptive activity using acetic acid induced writhing test, hot plate test and tail immersion test in mice. In a similar way a screening exercise was carried out to determine the antipyretic potential of the extract using yeast induced pyrexia method in rats. Administration of the extracts was applied to bo...

The NMDA receptor is central in the generation and maintenance of chronic pain. This receptor has several sites of modulation. One is the glutamate recognition site that can be blocked by (±)-3-(2-carboxypiperazin-yl)propyl-1-phosphoric acid or (±)-CPP. We investigated whether the effect of glial inhibition produced by propentophylline (PPF) can be enhanced when combined with (±)-CPP. We used S...

The antinociceptive activity of the methanolic extract of the leaves of Feronia limonia Linn. (Family Rutaceae) was investigated using acetic acid-induced writhing model and tail flick test in swiss albino mice. The extract produced about 26.01% ( p< 0.01), 39.88% ( p< 0.01) and 57.07% (p< 0.01) writhing inhibition at the dose of 100, 200 and 400 mg/kg of body weight respectively, which was com...

We have compared the antinociceptive effect of extradural lignocaine on somatic and visceral nociception in pregnant (n = 11) and non-pregnant rats (n = 9). Colorectal distension (CD) threshold and tail flick (TF) latency were measured as visceral and somatic nociception, respectively, for 60 min after extradural injection. On days 19, 20 and 21 of pregnancy, rats received lignocaine 200, 400 o...