نتایج جستجو برای: antinociceptive

تعداد نتایج: 4187  

Journal: :Molecules 2007
Fátima de Campos-Buzzi Pâmela Padaratz Aleandra Vergilina Meira Rogério Corrêa Ricardo José Nunes Valdir Cechinel-Filho

Nine acetamidochalcones were synthesized and evaluated as antinociceptive agents using the mice writhing test. Given intraperitoneally all the compounds were more effective than the two reference analgesic drugs (acetylsalicylic acid and acetaminophen) used for comparison. N-{4-[(2E)-3-(4-nitrophenyl)prop-2-enoyl]phenyl}acetamide (6) was the most effective compound and was therefore selected fo...

2011
Mariana Spetea Petra Windisch Yan Guo Indre Bileviciute-Ljungar Johannes Schütz Muhammad Faheem Asim Ilona P. Berzetei-Gurske Pal Riba Kornel Kiraly Susanna Fürst Mahmoud Al-Khrasani Helmut Schmidhammer

The synthesis and the effect of a combination of 6-glycine and 14-phenylpropoxy substitutions in N-methyl- and N-cycloproplymethylmorphinans on biological activities are described. Binding studies revealed that all new 14-phenylpropoxymorphinans (11-18) displayed high affinity to opioid receptors. Replacement of the 14-methoxy group with a phenylpropoxy group led to an enhancement in affinity t...

Journal: :medical journal of islamic republic of iran 0
h hosseinzadeh from the department of pharmacodynamy and toxicology, faculty o/pharmacy, mashhad university of medical sciences, p.o. box 91775-1365, mashhad, i.r. iran. me shooshtari

there are several reports that adenosine and carbamazepine have pharmacodynamic interaction. i n this study the antinociceptive interaction o f these two agents was evaluated in mice by the hot plate test. agents were injected intraperitoneally. 0.2 and 0.4 mg/kg doses of r-phenylisopropyladenosine (r-pia) substantially showed antinociceptive effects. carbamazepine had antinociceptive actions e...

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 2007
Damião P de Sousa Edison V M Júnior Fernando S Oliveira Reinaldo N de Almeida Xirley P Nunes José M Barbosa-Filho

Rotundifolone, a monoterpene isolated from the essential oil of the leaves of Mentha x villosa, is a constituent of several essential oils and known to have antinociceptive activity. Our recent study demonstrated that the analogues of rotundifolone showed also a significant antinociceptive effect. In the present report, to investigate the correlation between the structure and antinociceptive ac...

2011
Marjan Nassiri-Asl Sedighe-Sadat Hosseini Amir-Abdollah Zangivand Hesam Rahimi Freshteh Safdari

In this study, the antinociceptive effects of the gap junction blocker carbenoxolone and morphine were examined using the formalin test as a model of pain. We found that carbenoxolone was dose-dependently antinociceptive in both the first and second phases of the formalin test. Pretreatment with carbenoxolone increased antinociceptive effect of morphine in the first phase of formalin test. Also...

2002
Qi Jiang Henry I. Mosberg

Co-administration of 8 opioid agonists at doses which do not produce measurable antinociception were demonstrafed to produce an increase in the antinociceptive potency of morphine in the mouse tail-flick test. In contrast, co-administration of equi-antinociceptive combinations of a 8 agonist plus morphine for three days resulted in the development of less tolerance to morphine antinociceptive a...

2015
Soichiro Ide Hiroshi Satoyoshi Masabumi Minami Masamichi Satoh

BACKGROUND Although alterations in not only the pain sensitivity but also the analgesic effects of opioids have been reported under conditions of stress, the influence of unpredictable chronic mild stress (UCMS) on the antinociceptive effects of opioid analgesics remains to be fully investigated. The present study examined the influence of UCMS on the thermal pain sensitivity and antinociceptiv...

Journal: :iranian journal of basic medical sciences 0
mohammad ali mobasher 1 department of pharmaceutical biotechnology, faculty of pharmacy, shiraz university of medical sciences, shiraz, iran pharmaceutical sciences research center, shiraz university of medical sciences, shiraz, iran javad sajedianfard department of physiology, school of veterinary medicine, shiraz university, shiraz, iran akram jamshidzadeh pharmaceutical sciences research center, shiraz university of medical sciences, shiraz, iran naser naghdi department of physiology and pharmacology, institute pasture of iran, tehran, iran mohammad mehdi namvaran department of pharmaceutical biotechnology, faculty of pharmacy, shiraz university of medical sciences, shiraz, iran pharmaceutical sciences research center, shiraz university of medical sciences, shiraz, iran

objective(s):the relationship between tramadol, as an antinociceptive drug, and locus coeruleus (lc), the main noradrenergic nucleus of the brain that affects regulation and modulation of pain through descending noradrenergic pathways was investigated. materials and methods: male sprague-dawley rats were divided into four groups of 10 rats. the rats were fixed in stereotaxic instrument and then...

Journal: :jundishapur journal of natural pharmaceutical products 0
elahe rangriz department of pharmacology and toxicology, faculty of pharmacy, pharmaceutical sciences branch, islamic azad university, tehran, ir iran zahra mousavi department of pharmacology and toxicology, faculty of pharmacy, pharmaceutical sciences branch, islamic azad university, tehran, ir iran; department of pharmacology and toxicology, faculty of pharmacy, pharmaceutical sciences branch, islamic azad university, tehran, ir iran. tel: +98-2122640051(5), fax: +98-2122602059 parvaneh najafizadeh department of pharmacology, faculty of medicine, iran university of medical sciences, tehran, ir iran jinous asgarpanah young researchers and elite club, pharmaceutical sciences branch, islamic azad university, tehran, ir iran; department of pharmacognosy, faculty of pharmacy, pharmaceutical sciences branch, islamic azad university, tehran, ir iran

results all doses of g. vitellinum extract induced anti-nociception activity during the first and second phases of the formalin test. the extract showed a significant (p < 0.05) dose-related inhibition during the first phase compared to the control group. in the second phase of the formalin test, the extract showed analgesic activity comparable to the effect of morphine. in pre-treatment with n...

H HOSSEINZADEH, ME SHOOSHTARI,

There are several reports that adenosine and carbamazepine have pharmacodynamic interaction. I n this study the antinociceptive interaction o f these two agents was evaluated in mice by the hot plate test. Agents were injected intraperitoneally. 0.2 and 0.4 mg/kg doses of R-phenylisopropyladenosine (R-PIA) substantially showed antinociceptive effects. Carbamazepine had antinociceptive acti...

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