Two outstanding questions concerning antinuclear antibodies (ANAs) in lupus involve their pathogenic potential and their molecular signatures. To address these questions, a panel of 56 antinuclear and 47 nonnuclear binding monoclonal antibodies was rescued from four seropositive NZM2410 lupus mice. The monoclonals varied in their reactivity to nucleosomes, ssDNA, dsDNA, and glomerular substrate...

Sleep is hypothesized to play a restorative role on immune system. In addition, disturbed sleep is thought to impair host defense mechanisms. Chronic sleep deprivation is a common occurrence in modern society and has been observed in a number of chronic inflammatory conditions, such as systemic lupus erythematosus (SLE). New Zealand Black/New Zealand White (NZB/NZW) F1 mice develop an autoimmun...

Sweet syndrome (SS) (Acute Febrile Neutrophilic Dermatosis) has been reported in association with autoimmune phenomena including relapsing polychondritis, drug-induced lupus, and the development of antineutrophil cytoplasmic antibodies (ANCAs). However, a combination of these autoimmune features has not been reported. Herein, we report a case of drug-induced bullous SS with ocular and mucosal i...

We report here the case of a woman with joint pains found to have antinuclear antibodies and undetectable serum haemolytic complement. Investigation of her and her family members showed an inherited deficiency of C6.

Immunofluorescent techniques have been used extensively to detect the presence of antinuclear factors (ANF) in sera from patients with systemic lupus erythematosus and related disorders. Furthermore, morphological differences in the character of nuclear immunofluorescence have been considered to be of clinical as well as immunological significance (Casals, Friou, and Teague, 1963; Burnham, Fine...

Antinuclear antibodies (ANA) are antibodies that bind to several nuclear antigens. ANA have been reported in cancers, suggesting that they may have a role in the pathogenesis of malignancy [4,5]. Many studies have reported that NHL patients could display ANA antibodies [6,7]. This study assessed serum levels of ANA in NHL patients and examined its association with hematological, clinicopatholog...