Cough remains a major unmet clinical need, and preclinical animal models are not predictive for new antitussive agents. We have investigated the mechanisms and pharmacological sensitivity of ozone-induced hypertussive responses in rabbits and guinea pigs. Ozone induced a significant increase in cough frequency and a decrease in time to first cough to inhaled citric acid in both conscious guinea...

BACKGROUND Guaifenesin, a commonly used agent for the treatment of cough, is termed an expectorant since it is believed to alleviate cough discomfort by increasing sputum volume and decreasing its viscosity, thereby promoting effective cough. Despite its common usage, relatively few studies, yielding contrasting results, have been performed to investigate the action and efficacy of guaifenesin....

Eriobotrya japonica has been used as a medicinal plant for a long time, and its leaves are known to have many physiological actions such as anti-inflammatory, antitussive, and expectoran. In contrast, Eriobotrya japonica seeds are only known to contain amygdalin, and almost no investigations of its pharmacological action have been performed. Moreover, some anticancer agents such as adriamycin c...

Background: Noscapine is a water soluble alkaloid with antitussive property and very less toxicity. It is obtained from the Papaveraceae family. Recently, new pharmacological properties such as anticancer, anti stroke and anti-angiogenic effects are introduced. There is no scientific report on noscapine effect on reproductive system. The aim of present study was to determine in vitro effect of ...

conclusions these results showed the preventive effect of hydroethanolic extract of n. sativa on tracheal responsiveness of guinea pig model of copd, which was as effective as vitamin c. results the tracheal responsiveness to both methacholine and ovalbumin in guinea pigs with copd were significantly higher than those of controls (p < 0.001 for both cases). the tracheal responsiveness in the co...

Emblica officinalis (Amla) are widely used in the Indian system of medicine and believed to increase defense against diseases. This article discuses and summarizes important medicinal values of Emblica officinalis (EO). In this communication, we reviewed the applications of EO in cancer, diabetis, liver treatment, heart disease, ulcer, anemia and various other diseases. The use of EO as antioxi...