Abstract Tumor cells have different metabolism from normal cell, which is called as cancer metabolism. In cells, asparagine provided by synthetase (ASNS) aspartate. On the other hand, in tumor needed to be taken outside addition synthesized ASNS within because of rapid growth cells. Glioblastoma one aggressive brain tumors, and temozolomide frequently used. After glioblastoma acquire resistance...

BACKGROUND AND OBJECTIVES Pegylated-asparaginase (PEG-ASP) has been traditionally used as a second-line preparation in children with acute lymphoblastic leukemia (ALL) presenting with clinical allergy to native asparaginase (ASP) products. The main goal of the present study was to investigate the pharmacological effects of the administration of PEG-ASP given as a first-line product in children ...

nitric oxide is an important vasorelaxant factor that it inhibits platelet adhesion and proliferation of smooth muscle cells. no is synthesized from l-arginine by means of endothelial nitric oxide synthase (enos) which is an isoform of  nitric oxide synthase.in the present study, we examined  possible association between the 27 base pair (bp) repeat  polymorphism in intron 4 of the  enos3 gene ...

The enzyme L-asparaginase (L-asparagine amidohydrolase) catalyzes the breakdown of L-asparagine into aspartate and ammonia, which leads to an anti-neoplastic activity stemming from its capacity deplete concentrations in bloodstream, it is therefore used cases acute lymphoblastic leukemia (ALL) inhibit malignant cell growth. Nowadays, this anti-cancer enzyme, largely produced by Escherichia coli...

In the title compound, C(11)H(14)N(2)O(5)S, the amide O atom acts as a hydrogen-bond acceptor from a carboxyl-ate O atom and a secondary amino N atom. In addition, one of the sulfonyl O atoms and the carbonyl O atom of the carboxyl group also form hydrogen bonds with the primary amido N atom. These intermolecular hydrogen-bonding inter-actions give rise to a layer structure, with the layers par...

The presence of acrylamide, a mutagen and Group 2A carcinogen, in food, is health concern that might raise cancer risk. Acrylamide mainly formed the Maillard reaction between free asparagine reducing sugars, during industrial thermal food processing or home cooking, at temperature over 120°C. European Commission Regulation (EU) 2017/2158 established mitigation measures benchmarks for acrylamide...

The tendency to consume food with lower sugar content and alternatively healthy foods and food products are rising. High levels of sugar in date syrup might be used as a good alternative to sugar in various food products. Iran is one of the main producers of date fruit and it is possible to produce foods with high nutritional values from date to replace high-sugar content food....