BACKGROUND Rotator cuff tendons heal to bone with interposed scar tissue, which makes repairs prone to failure. The purpose of this study was to determine if the application of bone marrow-derived mesenchymal stem cells (MSCs) can improve rotator cuff healing after repair. HYPOTHESIS Application of MSCs to the repair site will result in superior results compared with controls on histologic an...

BACKGROUND A new treatment strategy is to target specific areas of the skeletal system that are prone to clinically significant osteoporotic fractures. We term this strategy as the "local treatment of osteoporosis". The study was performed to investigate the effect of alendronate-loaded calcium phosphate cement (CPC) as a novel drug delivery system for local treatment of osteoorosis. METHODS ...

PURPOSE To compare the biomechanical performance of medial row suture placement relative to the musculotendinous junction (MTJ) in a cadaveric transosseous equivalent suture bridge (TOE-SB) double-row (DR) rotator cuff repair (RCR) model. METHODS A TOE-SB DR technique was used to reattach experimentally created supraspinatus tendon tears in 9 pairs of human cadaveric shoulders. The medial row...

Objective(s): Tendon healing is substantially slow and often associated with suboptimal repair. Cell therapy is one of the promising methods to improve tendon repair. Blastema, a population of undifferentiated cells, represents characteristics of pluripotent mesenchymal stem cells and has the potentials to be used in regenerative medicine. The aim of this study was to ...

Tissue engineering is a promising approach to restore or replace damaged temporomandibular joint (TMJ) disc. However, constructing scaffold that can mimic biomechanical and biological properties of the natural TMJ disc remains challenge. In this study, three-dimensional (3D) printing technology was used fabricate polycaprolactone (PCL)/polyurethane (PU) scaffolds PU imitate region-specific The ...

To investigate the biomechanical performances of artificial cervical disc (ACD) prostheses, many studies have been conducted, either with sections cadavers under physiological loads or block-like testing fixtures obeying ASTM F2346 standard. Unfortunately, both methods are almost impossible to utilize for accurate results lifetime anti-fatigue experiments at least 10 million cycles due difficul...

BACKGROUND Although numerous suture-button fixation techniques for acromioclavicular (AC) joint reconstruction have been validated with biomechanical testing in the superior direction, clinical reports continue to demonstrate high rates of construct slippage and breakage. PURPOSE To compare the stability of a novel closed-loop double Endobutton construct with a commercially available cortical...

Since the anthropometric and biomechanical parameters role is effective in improving the quality of sports skills, researchers and sports scientists are interesting to identify and communicate between these factors. The purpose of this study was making relationship between some of anthropometrical and biomechanical parameter of girl swimmers in swimming breast strokes. Twenty girl Swimmers (mea...

BACKGROUND The objective of this study was to investigate the potency of platelet-rich plasma (PRP) combined with bone marrow mesenchymal stem cells (BMSCs) to promote tendon-bone healing in a rabbit model. METHODS In the in vitro study, the effects of PRP on osteogenic induction of BMSCs were analysed. Later, PRP with or without BMSCs was used in the rabbit model of anterior cruciate ligamen...