Functional plasticity of synaptic networks in the dentate gyrus has been implicated in the development of posttraumatic epilepsy and in cognitive dysfunction after traumatic brain injury, but little is known about potentially pathogenic changes in inhibitory circuits. We examined synaptic inhibition of dentate granule cells and excitability of surviving GABAergic hilar interneurons 8-13 weeks a...

One potential mechanism of temporal lobe epilepsy is recurrent excitation of dentate granule cells through aberrant sprouting of their axons (mossy fibers), which is found in many patients and animal models. However, correlations between the extent of mossy fiber sprouting and seizure frequency are weak. Additional potential sources of granule cell recurrent excitation that would not have been ...

Measurement of platelet granule release to detect inherited platelet secretion disorders (IPSDs) is essential for the evaluation of patients with abnormal bleeding and is necessary to distinguish which granule sub-types are affected and whether there is abnormal granule bio-synthesis or secretion. The radioactive serotonin incorporation and release assay, described before 1970, is still conside...

In the developing cerebellum, switching of the subunit composition of NMDA receptors occurs in granule cells from NR2B-containing receptors to NR2C-containing ones. We investigated the mechanisms underlying switching of NR2B and NR2C subunit composition in primary cultures of mouse granule cells at the physiological KCl concentration (5 mM). Granule cells extensively extended their neuritic pro...

Acute respiratory infection (ARI) is a that causes disruption of normal activities. Amoxicillin the antibiotic first choice generally given to patients with ARI. Compliance in use antibiotics for less than five days will determine success therapy so frequency drug also affects patient compliance taking medication. Granule mucoadhesive amoxicillin trihydrate formula designed addition chitosan po...

Representation of a granule, relation and operation between two granules are mainly researched in granular computing. Hyperbox granular computing classification algorithms (HBGrC) are proposed based on interval analysis. Firstly, a granule is represented as the hyperbox which is the Cartesian product of $N$ intervals for classification in the $N$-dimensional space. Secondly, the relation betwee...

The aim of this paper is to develop a rapid, and highly sensitive quantitative HPLC fingerprint method with multiple indicators by using the Compound Chinese Medicine Wuwei Changyanning granule and 5 herbs in the prescription. The quantitative fingerprint chromatogram with multiple indicators was investigated. ⅰ)6 compositions included rutin, gallic acid, chlorogenic acid, atractylenolideⅠ, pac...

OVERVIEW OF ADULT HIPPOCAMPAL NEUROGENESIS The dentate gyrus represents a unique system for the study of interactions between neuronal development and experience. While this hippocampal subfield has been extensively investigated in relationship to the ongoing process of adult neurogenesis, the mnemonic contributions of mature granule neurons have remained enigmatic. Much of the rationale for fo...

Granule breakage is an important rate process in wet granulation that promotes product uniformity and controls size strength. In this work, a model to predict granule proposed experimentally validated. The assumes exponential of the surviving granules, dependent on probability breakage; function powder binder properties, as well operating parameters. Validation experiments were performed with b...